FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951840293> ?p ?o ?g. }

• W2951840293 endingPage "3224" @default.
• W2951840293 startingPage "3218" @default.
• W2951840293 abstract "Abstract Malignant pleural mesothelioma (MPM) is a highly aggressive form of cancer, with a median survival of less than 1 year. It is well known that the hyaluronan (HA) receptor CD44 is highly expressed by MPM cells and is reported to be correlated with a poor prognosis. We herein report on the development of a new type if drug delivery system against CD44 that involves the use of lipid nanoparticles (LNPs) equipped with a new type of HA derivative. In this study, we evaluated HA-lipid conjugation (HAL) via the end of the HA molecule through reductive amination, a process that allowed the carboxylate group to remain intact. As a result, the HAL-modified LNP appears to be a potent nanoparticle for dealing with MPM. Surprisingly, the use of a combination of a cationic lipid and HAL had a synergistic effect on cellular uptake in MPM and consequently permitted an anti-cancer drug such as cis-diamminedichloro-platinum(II) (CDDP). Intrapleural injection of CDDP-loaded HAL-LNP (1.5 mg/kg as CDDP) per week significantly suppressed the progression of this type of cancer in an MPM orthotopic model. These results suggest that HAL-modified LNP represents a potent delivery system for MPM cells that express high levels of CD44." @default.
• W2951840293 created "2019-06-27" @default.
• W2951840293 creator A5006918664 @default.
• W2951840293 creator A5015662992 @default.
• W2951840293 creator A5020560198 @default.
• W2951840293 creator A5021660272 @default.
• W2951840293 creator A5050984306 @default.
• W2951840293 creator A5061967603 @default.
• W2951840293 creator A5064568192 @default.
• W2951840293 date "2019-10-01" @default.
• W2951840293 modified "2023-09-26" @default.
• W2951840293 title "Synergistic Enhancement of Cellular Uptake With CD44-Expressing Malignant Pleural Mesothelioma by Combining Cationic Liposome and Hyaluronic Acid–Lipid Conjugate" @default.
• W2951840293 cites W1968568156 @default.
• W2951840293 cites W1969245473 @default.
• W2951840293 cites W1974889520 @default.
• W2951840293 cites W1985722075 @default.
• W2951840293 cites W1997627303 @default.
• W2951840293 cites W2014928486 @default.
• W2951840293 cites W2021218243 @default.
• W2951840293 cites W2023389405 @default.
• W2951840293 cites W2028937577 @default.
• W2951840293 cites W2030105788 @default.
• W2951840293 cites W2035311100 @default.
• W2951840293 cites W2040899514 @default.
• W2951840293 cites W2043411450 @default.
• W2951840293 cites W2050291724 @default.
• W2951840293 cites W2062671628 @default.
• W2951840293 cites W2091993321 @default.
• W2951840293 cites W2101834873 @default.
• W2951840293 cites W2101952912 @default.
• W2951840293 cites W2102627969 @default.
• W2951840293 cites W2103305097 @default.
• W2951840293 cites W2104043272 @default.
• W2951840293 cites W2104259434 @default.
• W2951840293 cites W2108066008 @default.
• W2951840293 cites W2113220153 @default.
• W2951840293 cites W2120198019 @default.
• W2951840293 cites W2127053176 @default.
• W2951840293 cites W2137042343 @default.
• W2951840293 cites W2147121849 @default.
• W2951840293 cites W2161223700 @default.
• W2951840293 cites W2169713909 @default.
• W2951840293 cites W2177556708 @default.
• W2951840293 cites W2339452820 @default.
• W2951840293 cites W2520371846 @default.
• W2951840293 cites W2586604110 @default.
• W2951840293 cites W2588857805 @default.
• W2951840293 cites W2604295466 @default.
• W2951840293 cites W2604858494 @default.
• W2951840293 cites W2606799384 @default.
• W2951840293 cites W2612417761 @default.
• W2951840293 cites W2767259168 @default.
• W2951840293 cites W2774248760 @default.
• W2951840293 cites W2782822015 @default.
• W2951840293 cites W2783708904 @default.
• W2951840293 cites W2799300331 @default.
• W2951840293 cites W2801311742 @default.
• W2951840293 cites W2803870411 @default.
• W2951840293 cites W2886722094 @default.
• W2951840293 cites W2897846488 @default.
• W2951840293 cites W4242063371 @default.
• W2951840293 doi "https://doi.org/10.1016/j.xphs.2019.06.012" @default.
• W2951840293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31229434" @default.
• W2951840293 hasPublicationYear "2019" @default.
• W2951840293 type Work @default.
• W2951840293 sameAs 2951840293 @default.
• W2951840293 citedByCount "12" @default.
• W2951840293 countsByYear W29518402932020 @default.
• W2951840293 countsByYear W29518402932021 @default.
• W2951840293 countsByYear W29518402932022 @default.
• W2951840293 countsByYear W29518402932023 @default.
• W2951840293 crossrefType "journal-article" @default.
• W2951840293 hasAuthorship W2951840293A5006918664 @default.
• W2951840293 hasAuthorship W2951840293A5015662992 @default.
• W2951840293 hasAuthorship W2951840293A5020560198 @default.
• W2951840293 hasAuthorship W2951840293A5021660272 @default.
• W2951840293 hasAuthorship W2951840293A5050984306 @default.
• W2951840293 hasAuthorship W2951840293A5061967603 @default.
• W2951840293 hasAuthorship W2951840293A5064568192 @default.
• W2951840293 hasBestOaLocation W29518402932 @default.
• W2951840293 hasConcept C104317684 @default.
• W2951840293 hasConcept C105702510 @default.
• W2951840293 hasConcept C134306372 @default.
• W2951840293 hasConcept C141071460 @default.
• W2951840293 hasConcept C142724271 @default.
• W2951840293 hasConcept C1491633281 @default.
• W2951840293 hasConcept C155887181 @default.
• W2951840293 hasConcept C183882617 @default.
• W2951840293 hasConcept C185154212 @default.
• W2951840293 hasConcept C185592680 @default.
• W2951840293 hasConcept C188027245 @default.
• W2951840293 hasConcept C197336794 @default.
• W2951840293 hasConcept C2777407522 @default.
• W2951840293 hasConcept C2777529286 @default.
• W2951840293 hasConcept C2779127879 @default.
• W2951840293 hasConcept C2780932548 @default.
• W2951840293 hasConcept C33923547 @default.
• W2951840293 hasConcept C502942594 @default.

• next