Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951852806> ?p ?o ?g. }
- W2951852806 abstract "Galectins are potent immunomodulators that regulate maternal immune responses in pregnancy and prevent the rejection of the semi-allogeneic fetus that also occurs in miscarriages. We previously identified a gene cluster on Chromosome 19 that expresses a subfamily of galectins, including galectin-13 (Gal-13) and galectin-14 (Gal-14), which emerged in anthropoid primates. These galectins are expressed only by the placenta and induce the apoptosis of activated T lymphocytes, possibly contributing to a shifted maternal immune balance in pregnancy. The placental expression of Gal-13 and Gal-14 is decreased in preeclampsia, a life-threatening obstetrical syndrome partly attributed to maternal anti-fetal rejection. This study is aimed at revealing the effects of Gal-13 and Gal-14 on T cell functions and comparing the expression of these galectins in placentas from healthy pregnancies and miscarriages. First-trimester placentas were collected from miscarriages and elective termination of pregnancies, tissue microarrays were constructed, and then the expression of Gal-13 and Gal-14 was analyzed by immunohistochemistry and immunoscoring. Recombinant Gal-13 and Gal-14 were expressed and purified, and their effects were investigated on primary peripheral blood T cells. The binding of Gal-13 and Gal-14 to T cells and the effects of these galectins on apoptosis, activation marker (CD25, CD71, CD95, HLA-DR) expression and cytokine (IL-1β, IL-6, IL-8, IL-10, IFNγ) production of T cells were examined by flow cytometry. Gal-13 and Gal-14 are primarily expressed by the syncytiotrophoblast at the maternal-fetal interface in the first trimester, and their placental expression is decreased in miscarriages compared to first-trimester controls. Recombinant Gal-13 and Gal-14 bind to T cells in a population- and activation-dependent manner. Gal-13 and Gal-14 induce apoptosis of Th and Tc cell populations, regardless of their activation status. Out of the investigated activation markers, Gal-14 decreases the cell surface expression of CD71, Gal-13 increases the expression of CD25, and both galectins increase the expression of CD95 on T cells. Non-activated T cells produce larger amounts of IL-8 in the presence of Gal-13 or Gal-14. In conclusion, these results show that Gal-13 and Gal-14 already provide an immunoprivileged environment at the maternal-fetal interface during early pregnancy, and their reduced expression is related to miscarriages." @default.
- W2951852806 created "2019-06-27" @default.
- W2951852806 creator A5002768538 @default.
- W2951852806 creator A5005584876 @default.
- W2951852806 creator A5006739622 @default.
- W2951852806 creator A5019856778 @default.
- W2951852806 creator A5021044213 @default.
- W2951852806 creator A5021054262 @default.
- W2951852806 creator A5033629280 @default.
- W2951852806 creator A5040820733 @default.
- W2951852806 creator A5043404288 @default.
- W2951852806 creator A5048055174 @default.
- W2951852806 creator A5048773415 @default.
- W2951852806 creator A5055170771 @default.
- W2951852806 creator A5059225656 @default.
- W2951852806 creator A5065944362 @default.
- W2951852806 creator A5067511554 @default.
- W2951852806 creator A5069889713 @default.
- W2951852806 creator A5073354905 @default.
- W2951852806 creator A5073513278 @default.
- W2951852806 creator A5076715598 @default.
- W2951852806 creator A5085524384 @default.
- W2951852806 creator A5089358249 @default.
- W2951852806 date "2019-06-19" @default.
- W2951852806 modified "2023-10-13" @default.
- W2951852806 title "Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response" @default.
- W2951852806 cites W1008189539 @default.
- W2951852806 cites W1248200877 @default.
- W2951852806 cites W139741139 @default.
- W2951852806 cites W1459407139 @default.
- W2951852806 cites W1488556240 @default.
- W2951852806 cites W1498159349 @default.
- W2951852806 cites W1509926487 @default.
- W2951852806 cites W1511621323 @default.
- W2951852806 cites W1524427612 @default.
- W2951852806 cites W1541574343 @default.
- W2951852806 cites W1550148927 @default.
- W2951852806 cites W1550488314 @default.
- W2951852806 cites W1564674105 @default.
- W2951852806 cites W1581845558 @default.
- W2951852806 cites W1593047235 @default.
- W2951852806 cites W1605753053 @default.
- W2951852806 cites W1608751525 @default.
- W2951852806 cites W1630880489 @default.
- W2951852806 cites W1874363102 @default.
- W2951852806 cites W1963777456 @default.
- W2951852806 cites W1964380344 @default.
- W2951852806 cites W1965897259 @default.
- W2951852806 cites W1966673624 @default.
- W2951852806 cites W1970185637 @default.
- W2951852806 cites W1972766975 @default.
- W2951852806 cites W1973421833 @default.
- W2951852806 cites W1975949520 @default.
- W2951852806 cites W1976712004 @default.
- W2951852806 cites W1976853389 @default.
- W2951852806 cites W1977079752 @default.
- W2951852806 cites W1980993209 @default.
- W2951852806 cites W1981141937 @default.
- W2951852806 cites W1983383847 @default.
- W2951852806 cites W1983754013 @default.
- W2951852806 cites W1984721740 @default.
- W2951852806 cites W1986217940 @default.
- W2951852806 cites W1986223776 @default.
- W2951852806 cites W1990795537 @default.
- W2951852806 cites W1991413654 @default.
- W2951852806 cites W1993271798 @default.
- W2951852806 cites W1995272947 @default.
- W2951852806 cites W1996168096 @default.
- W2951852806 cites W1996532305 @default.
- W2951852806 cites W1997528898 @default.
- W2951852806 cites W2001743415 @default.
- W2951852806 cites W2006865926 @default.
- W2951852806 cites W2007671824 @default.
- W2951852806 cites W2008834815 @default.
- W2951852806 cites W2009657056 @default.
- W2951852806 cites W2010101647 @default.
- W2951852806 cites W2018318831 @default.
- W2951852806 cites W2020151812 @default.
- W2951852806 cites W2020565855 @default.
- W2951852806 cites W2022431722 @default.
- W2951852806 cites W2023300047 @default.
- W2951852806 cites W2024384977 @default.
- W2951852806 cites W2025889554 @default.
- W2951852806 cites W2026398217 @default.
- W2951852806 cites W2028530728 @default.
- W2951852806 cites W2028570074 @default.
- W2951852806 cites W2028983214 @default.
- W2951852806 cites W2029273918 @default.
- W2951852806 cites W2029399275 @default.
- W2951852806 cites W2029480896 @default.
- W2951852806 cites W2030829786 @default.
- W2951852806 cites W2031594119 @default.
- W2951852806 cites W2034759328 @default.
- W2951852806 cites W2035426088 @default.
- W2951852806 cites W2036283983 @default.
- W2951852806 cites W2036421581 @default.
- W2951852806 cites W2036520114 @default.
- W2951852806 cites W2038019990 @default.
- W2951852806 cites W2041659209 @default.
- W2951852806 cites W2043028243 @default.