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• W2951857201 abstract "Dupilumab is a fully human monoclonal IgG4 antibody that blocks IL-4 and IL-13 signaling. Its efficacy has been assessed across a range of atopic diseases, due to its ability to inhibit T helper cell 2 (Th2) mediated inflammation. It has already been approved in the USA and Europe for the treatment of atopic dermatitis. Recently, it also gained approval in the USA as add-on treatment for moderate-to-severe asthma in adolescents and adults. Phase II and III randomized controlled trials have demonstrated improvements in asthma exacerbation rates, FEV1, oral glucocorticoid use and a range of patient-reported outcomes, with a favorable safety profile. This article will review the available clinical trial data relating to the efficacy and safety of dupilumab in the management of asthma and related atopic respiratory conditions." @default.
• W2951857201 created "2019-06-27" @default.
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• W2951857201 date "2019-07-01" @default.
• W2951857201 modified "2023-09-26" @default.
• W2951857201 title "Dupilumab in the treatment of asthma" @default.
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• W2951857201 doi "https://doi.org/10.2217/imt-2019-0008" @default.
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