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- W2951858178 abstract "Clostridium difficile is the leading cause of hospital-borne infections occurring when the natural intestinal flora is depleted following antibiotic treatment. We present i MLTC804cdf, an extensively curated reconstructed metabolic network for the C. difficile pathogenic strain 630. i MLTC804cdf contains 804 genes, 705 metabolites and 766 metabolic, 145 exchange and 118 transport reactions. i MLTC804cdf is the most complete and accurate metabolic reconstruction of a gram-positive anaerobic bacteria to date. We validate the model with simulated growth assays in different media and carbon sources and use it to predict essential genes. We obtain 88.8% accuracy in the prediction of gene essentiality when compared to experimental data for B. subtilis homologs. We predict the existence of 83 essential genes and 68 essential gene pairs, a number of which are unique to C. difficile and have non-existing or predicted non-essential human homologs. For 19 of these potential therapeutic targets, we find 72 inhibitors of homologous proteins that could serve as starting points in the development of new antibiotics, including approved drugs with the potential for drug repositioning." @default.
- W2951858178 created "2019-06-27" @default.
- W2951858178 creator A5007968708 @default.
- W2951858178 creator A5019812910 @default.
- W2951858178 creator A5035097169 @default.
- W2951858178 date "2014-07-09" @default.
- W2951858178 modified "2023-10-16" @default.
- W2951858178 title "A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors" @default.
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- W2951858178 doi "https://doi.org/10.1101/006932" @default.
- W2951858178 hasPublicationYear "2014" @default.
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