Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951871640> ?p ?o ?g. }
- W2951871640 abstract "Mass and growth rate are highly integrative measures of cell physiology not discernable via genomic measurements. Here, we introduce a microfluidic platform enabling direct measurement of single-cell mass and growth rate upstream of highly multiplexed single-cell profiling such as single-cell RNA sequencing. We resolve transcriptional signatures associated with single-cell mass and growth rate in L1210 and FL5.12 cell lines and activated CD8+ T cells. Further, we demonstrate a framework using these linked measurements to characterize biophysical heterogeneity in a patient-derived glioblastoma cell line with and without drug treatment. Our results highlight the value of coupled phenotypic metrics in guiding single-cell genomics." @default.
- W2951871640 created "2019-06-27" @default.
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- W2951871640 date "2018-11-27" @default.
- W2951871640 modified "2023-10-16" @default.
- W2951871640 title "Linking single-cell measurements of mass, growth rate, and gene expression" @default.
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- W2951871640 doi "https://doi.org/10.1186/s13059-018-1576-0" @default.
- W2951871640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6260722" @default.
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