Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951882214> ?p ?o ?g. }
- W2951882214 endingPage "626" @default.
- W2951882214 startingPage "619" @default.
- W2951882214 abstract "The effects of diol-ginsenoside fraction (Diol-GF) and triol-ginsenoside fraction (Triol-GF) from Korean Red Ginseng on the development of type 1 diabetes (T1D) were examined in diabetes-prone biobreeding (DP-BB) rats that spontaneously develop T1D through an autoimmune process. DP-BB female rats were treated with Diol-GF or Triol-GF daily from the age of 3–4 weeks up to 11–12 weeks (1 mg/g body weight). Diol-GF delayed the onset, and reduced the incidence, of T1D. Islets of Diol-GF–treated DP-BB rats showed significantly lower insulitis and preserved higher plasma and pancreatic insulin levels. Diol-GF failed to change the proportion of lymphocyte subsets such as T cells, natural killer cells, and macrophages in the spleen and blood. Diol-GF had no effect on the ability of DP-BB rat splenocytes to induce diabetes in recipients. Diol-GF and diol-ginsenoside Rb1 significantly decreased tumor necrosis factor α production, whereas diol-ginsenosides Rb1 and Rd decreased interleukin 1β production in RAW264.7 cells. Furthermore, mixed cytokine- and chemical-induced β-cell cytotoxicity was greatly inhibited by Diol-GF and diol-ginsenosides Rc and Rd in RIN5mF cells. However, nitric oxide production in RAW264.7 cells was unaffected by diol-ginsenosides. Diol-GF, but not Triol-GF, significantly delayed the development of insulitis and T1D in DP-BB rats. The antidiabetogenic action of Diol-GF may result from the decrease in cytokine production and increase in β-cell resistance to cytokine/free radical–induced cytotoxicity." @default.
- W2951882214 created "2019-06-27" @default.
- W2951882214 creator A5000551501 @default.
- W2951882214 creator A5052669348 @default.
- W2951882214 creator A5065005770 @default.
- W2951882214 creator A5066115078 @default.
- W2951882214 date "2020-07-01" @default.
- W2951882214 modified "2023-09-27" @default.
- W2951882214 title "Diol-ginsenosides from Korean Red Ginseng delay the development of type 1 diabetes in diabetes-prone biobreeding rats" @default.
- W2951882214 cites W1563641110 @default.
- W2951882214 cites W1598741049 @default.
- W2951882214 cites W1935867447 @default.
- W2951882214 cites W1964666593 @default.
- W2951882214 cites W1978879939 @default.
- W2951882214 cites W1986882841 @default.
- W2951882214 cites W1989683994 @default.
- W2951882214 cites W1990802251 @default.
- W2951882214 cites W1996673479 @default.
- W2951882214 cites W1996869464 @default.
- W2951882214 cites W1999220854 @default.
- W2951882214 cites W2030244963 @default.
- W2951882214 cites W2030660601 @default.
- W2951882214 cites W2034100989 @default.
- W2951882214 cites W2035756597 @default.
- W2951882214 cites W2039236651 @default.
- W2951882214 cites W2040659217 @default.
- W2951882214 cites W2047380363 @default.
- W2951882214 cites W2047726392 @default.
- W2951882214 cites W2054905889 @default.
- W2951882214 cites W2058592841 @default.
- W2951882214 cites W2088154284 @default.
- W2951882214 cites W2095720372 @default.
- W2951882214 cites W2096224929 @default.
- W2951882214 cites W2096864643 @default.
- W2951882214 cites W2097351629 @default.
- W2951882214 cites W2104491684 @default.
- W2951882214 cites W2105410633 @default.
- W2951882214 cites W2110543615 @default.
- W2951882214 cites W2121115321 @default.
- W2951882214 cites W2124995095 @default.
- W2951882214 cites W2132761905 @default.
- W2951882214 cites W2135982188 @default.
- W2951882214 cites W2150316108 @default.
- W2951882214 cites W2171932333 @default.
- W2951882214 cites W2290746176 @default.
- W2951882214 cites W2406481035 @default.
- W2951882214 cites W2423298231 @default.
- W2951882214 cites W2427061792 @default.
- W2951882214 cites W2431312567 @default.
- W2951882214 cites W2469049214 @default.
- W2951882214 cites W248493959 @default.
- W2951882214 cites W2511609099 @default.
- W2951882214 cites W2572946219 @default.
- W2951882214 cites W2610607638 @default.
- W2951882214 cites W2777382514 @default.
- W2951882214 cites W4231035635 @default.
- W2951882214 doi "https://doi.org/10.1016/j.jgr.2019.06.001" @default.
- W2951882214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7322746" @default.
- W2951882214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32617042" @default.
- W2951882214 hasPublicationYear "2020" @default.
- W2951882214 type Work @default.
- W2951882214 sameAs 2951882214 @default.
- W2951882214 citedByCount "5" @default.
- W2951882214 countsByYear W29518822142021 @default.
- W2951882214 countsByYear W29518822142022 @default.
- W2951882214 crossrefType "journal-article" @default.
- W2951882214 hasAuthorship W2951882214A5000551501 @default.
- W2951882214 hasAuthorship W2951882214A5052669348 @default.
- W2951882214 hasAuthorship W2951882214A5065005770 @default.
- W2951882214 hasAuthorship W2951882214A5066115078 @default.
- W2951882214 hasBestOaLocation W29518822141 @default.
- W2951882214 hasConcept C126322002 @default.
- W2951882214 hasConcept C134018914 @default.
- W2951882214 hasConcept C142724271 @default.
- W2951882214 hasConcept C178790620 @default.
- W2951882214 hasConcept C185592680 @default.
- W2951882214 hasConcept C204787440 @default.
- W2951882214 hasConcept C2776539398 @default.
- W2951882214 hasConcept C2778690821 @default.
- W2951882214 hasConcept C2779232237 @default.
- W2951882214 hasConcept C2779515768 @default.
- W2951882214 hasConcept C2781306241 @default.
- W2951882214 hasConcept C2910036229 @default.
- W2951882214 hasConcept C71924100 @default.
- W2951882214 hasConceptScore W2951882214C126322002 @default.
- W2951882214 hasConceptScore W2951882214C134018914 @default.
- W2951882214 hasConceptScore W2951882214C142724271 @default.
- W2951882214 hasConceptScore W2951882214C178790620 @default.
- W2951882214 hasConceptScore W2951882214C185592680 @default.
- W2951882214 hasConceptScore W2951882214C204787440 @default.
- W2951882214 hasConceptScore W2951882214C2776539398 @default.
- W2951882214 hasConceptScore W2951882214C2778690821 @default.
- W2951882214 hasConceptScore W2951882214C2779232237 @default.
- W2951882214 hasConceptScore W2951882214C2779515768 @default.
- W2951882214 hasConceptScore W2951882214C2781306241 @default.
- W2951882214 hasConceptScore W2951882214C2910036229 @default.
- W2951882214 hasConceptScore W2951882214C71924100 @default.
- W2951882214 hasIssue "4" @default.