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- W2951890588 abstract "Abstract Many small interfering RNA (siRNA) carriers have been developed over the years, mostly based on cationic lipids and polymers that can condense siRNA into nanoparticle complexes and aid in endosomal escape. In comparison, development of charge‐neutral siRNA carriers to avoid or reduce nonspecific binding, aggregation, and toxicity is limited, due to a lack of mechanisms for carrier‐siRNA association beyond electrostatic interaction. Here, a unique, charge‐neutral, biomimetic platform is reported, mimicking the natural state of functional RNA, ribonucleoprotein (RNP). This RNP architecture is simple to make, precise in assembly stoichiometry, stable in serum, and biocompatible. Gene knockdown is achieved in vitro and in vivo, demonstrating excellent potential for translation." @default.
- W2951890588 created "2019-06-27" @default.
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- W2951890588 date "2019-06-24" @default.
- W2951890588 modified "2023-10-17" @default.
- W2951890588 title "Ribonucleoprotein: A Biomimetic Platform for Targeted siRNA Delivery" @default.
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- W2951890588 doi "https://doi.org/10.1002/adfm.201902221" @default.
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