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- W2951919130 abstract "Perturbations in B cells are a hallmark of HIV-1 infection. This is signified by increased numbers of exhausted CD21neg memory B cells, driven by continuous antigen-specific and bystander activation. Using high-dimensional flow cytometry, we demonstrate that this exhausted phenotype is also prevalent among peripheral antigen-inexperienced naive and marginal zone (MZ) B cells in acute and chronic HIV-1 infection. A substantial fraction of naive and MZ B cells exhibit down-regulated CD21 levels and diminished response to B cell receptor (BCR)–dependent stimulation. Compared with CD21pos subsets, the CD21neg naive and MZ B cells differ in the expression of chemokine receptors and activation markers. Effective antiretroviral treatment normalizes peripheral naive and MZ B cell populations. Our results emphasize a more widely spread impairment of B cells in HIV-1 infection than previously appreciated, including antigen-inexperienced cells. This highlights the importance of monitoring functional capacities of naive B cells in HIV-1 infection, as exhausted CD21neg naive B cells may severely impair induction of novel B cell responses." @default.
- W2951919130 created "2019-06-27" @default.
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- W2951919130 date "2019-06-20" @default.
- W2951919130 modified "2023-10-17" @default.
- W2951919130 title "Widespread B cell perturbations in HIV-1 infection afflict naive and marginal zone B cells" @default.
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- W2951919130 cites W1686167184 @default.
- W2951919130 cites W174593482 @default.
- W2951919130 cites W1971833928 @default.
- W2951919130 cites W1974089752 @default.
- W2951919130 cites W1975673932 @default.
- W2951919130 cites W1978398372 @default.
- W2951919130 cites W1978436252 @default.
- W2951919130 cites W1978693882 @default.
- W2951919130 cites W1980193047 @default.
- W2951919130 cites W1981981290 @default.
- W2951919130 cites W1982595765 @default.
- W2951919130 cites W1987039284 @default.
- W2951919130 cites W1987962124 @default.
- W2951919130 cites W1988901043 @default.
- W2951919130 cites W1991698426 @default.
- W2951919130 cites W1997677784 @default.
- W2951919130 cites W2008838198 @default.
- W2951919130 cites W2010959676 @default.
- W2951919130 cites W2013703920 @default.
- W2951919130 cites W2014334082 @default.
- W2951919130 cites W2016381774 @default.
- W2951919130 cites W2048787904 @default.
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- W2951919130 cites W2080215939 @default.
- W2951919130 cites W2080471324 @default.
- W2951919130 cites W2080746125 @default.
- W2951919130 cites W2083685302 @default.
- W2951919130 cites W2092168645 @default.
- W2951919130 cites W2097594050 @default.
- W2951919130 cites W2099069940 @default.
- W2951919130 cites W2101495681 @default.
- W2951919130 cites W2108096886 @default.
- W2951919130 cites W2111964236 @default.
- W2951919130 cites W2113783843 @default.
- W2951919130 cites W2115101818 @default.
- W2951919130 cites W2118425309 @default.
- W2951919130 cites W2120079411 @default.
- W2951919130 cites W2121096721 @default.
- W2951919130 cites W2122280827 @default.
- W2951919130 cites W2129723413 @default.
- W2951919130 cites W2133212359 @default.
- W2951919130 cites W2134276413 @default.
- W2951919130 cites W2135151522 @default.
- W2951919130 cites W2151587318 @default.
- W2951919130 cites W2158528364 @default.
- W2951919130 cites W2162633432 @default.
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- W2951919130 cites W2171149970 @default.
- W2951919130 cites W2297345677 @default.
- W2951919130 cites W2301596770 @default.
- W2951919130 cites W2315176554 @default.
- W2951919130 cites W2323626307 @default.
- W2951919130 cites W2342697778 @default.
- W2951919130 cites W2472400470 @default.
- W2951919130 cites W2509683982 @default.
- W2951919130 cites W2526682386 @default.
- W2951919130 cites W2541574334 @default.
- W2951919130 cites W2618433578 @default.
- W2951919130 cites W2803534335 @default.
- W2951919130 cites W2804790952 @default.
- W2951919130 cites W2884366659 @default.
- W2951919130 cites W2888189924 @default.
- W2951919130 cites W2952125308 @default.
- W2951919130 cites W312480887 @default.
- W2951919130 cites W4240098044 @default.
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- W2951919130 doi "https://doi.org/10.1084/jem.20181124" @default.
- W2951919130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6719425" @default.
- W2951919130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31221742" @default.
- W2951919130 hasPublicationYear "2019" @default.
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