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- W29519242 abstract "During the “suicidal” reductive activation of carbon tetrachloride (CCl4) by NADPH-reduced rat liver microsomes, cytochrome P-450 is inactivated and haem, the prosthetic group of the cytochrome, is lost (de Groot and Haas, 1981). The loss of haem was found to be equimolar to that of cytochrome P-450 and it is due to irreversible modification of the porphyrin tetrapyrrolic structure (Manno et al., 1986). In a purely chemical system using sodium dithionite as the reducing agent and methaemalbumin (MHA, a water soluble complex of haem with human albumin) as the “suicidal” activator, CCl4 was also responsible for a dramatic loss of haem and haem-derived protoporphyrin IX (Manno et al., 1987a). Moreover, in preliminary experiments using a mixed system containing both microsomes and exogenous haem in the presence of NADPH, the CCl4-dependent loss of haem was greater than that found in similar incubations containing microsomes but no MHA (unpublished results), suggesting that exogenous haem was able, in the presence of microsomes, to catalyse its own “suicidal” destruction by promoting the NADPH-dependent activation of CCl4. The aim of the present study was to investigate the mechanism of the CCl4-dependent destruction of haem using enzymatic and mixed enzymatic and non-enzymatic systems." @default.
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- W29519242 date "1988-01-01" @default.
- W29519242 modified "2023-09-26" @default.
- W29519242 title "Enzymatic and/or Non-Enzymatic “Suicidal” Activation of Carbon Tetrachloride by Heam and Cytochrome P-450" @default.
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- W29519242 doi "https://doi.org/10.1007/978-3-642-73113-6_54" @default.
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