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- W2951925287 abstract "Abstract Toxoplasma gondii is a common zoonotic infection of humans and estimates indicate that 1-2 billion people are chronically infected. Although largely asymptomatic, chronic infection poses risk of serious disease due to reactivation should immunity decline. Current therapies for toxoplasmosis only control acute infection caused by actively proliferating tachyzoites but do not eradicate the chronic tissue cyst stages. As well, there are considerable adverse side effects of the most commonly used therapy of combined sulfadiazine and pyrimethamine. Targeting the folate pathway is also an effective treatment for malaria, caused by the related parasites Plasmodium spp., suggesting common agents might be used to treat both infections. Here we evaluated currently approved and newly emerging medicines for malaria to determine if such compounds might also prove useful for treating toxoplasmosis. Surprisingly, the majority of anti-malarial compounds being used currently or in development for treatment of malaria were only modestly effective at inhibiting in vitro growth of T. gondii tachyzoites. These findings suggest that many essential processes in P. falciparum that are targeted by anti-malarial compounds are either divergent, or non-essential in T. gondii , thus limiting options for repurposing of current antimalarial medicines for toxoplasmosis." @default.
- W2951925287 created "2019-06-27" @default.
- W2951925287 creator A5029982946 @default.
- W2951925287 creator A5031443037 @default.
- W2951925287 creator A5071531643 @default.
- W2951925287 creator A5088068003 @default.
- W2951925287 date "2018-05-08" @default.
- W2951925287 modified "2023-09-24" @default.
- W2951925287 title "Evaluation of current and emerging anti-malarial medicines for inhibition of Toxoplasma gondii growth in vitro" @default.
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- W2951925287 doi "https://doi.org/10.1101/316455" @default.
- W2951925287 hasPublicationYear "2018" @default.
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