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- W2951925802 endingPage "540" @default.
- W2951925802 startingPage "527" @default.
- W2951925802 abstract "Changes in gene regulation have long been thought to play an important role in primate evolution. However, although a number of studies have compared genome-wide gene expression patterns across primate species, fewer have investigated the gene regulatory mechanisms that underlie such patterns, or the relative contribution of drift versus selection. Here, we profiled genome-scale DNA methylation levels in blood samples from five of the six extant species of the baboon genus Papio (4-14 individuals per species). This radiation presents the opportunity to investigate DNA methylation divergence at both shallow and deeper timescales (0.380-1.4 My). In contrast to studies in human populations, but similar to studies in great apes, DNA methylation profiles clearly mirror genetic and geographic structure. Divergence in DNA methylation proceeds fastest in unannotated regions of the genome and slowest in regions of the genome that are likely more constrained at the sequence level (e.g., gene exons). Both heuristic approaches and Ornstein-Uhlenbeck models suggest that DNA methylation levels at a small set of sites have been affected by positive selection, and that this class is enriched in functionally relevant contexts, including promoters, enhancers, and CpG islands. Our results thus indicate that the rate and distribution of DNA methylation changes across the genome largely mirror genetic structure. However, at some CpG sites, DNA methylation levels themselves may have been a target of positive selection, pointing to loci that could be important in connecting sequence variation to fitness-related traits." @default.
- W2951925802 created "2019-06-27" @default.
- W2951925802 creator A5036208626 @default.
- W2951925802 creator A5053501980 @default.
- W2951925802 creator A5070647499 @default.
- W2951925802 creator A5074476246 @default.
- W2951925802 creator A5089124760 @default.
- W2951925802 date "2018-12-05" @default.
- W2951925802 modified "2023-10-16" @default.
- W2951925802 title "Evolution of DNA Methylation in Papio Baboons" @default.
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