Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951932018> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W2951932018 abstract "Once considered to be isolation artifacts or chemical mistakes of nature, the number of naturally occurring organohalogen compounds has grown from a dozen in 1954 to >5000 today. Of these, at least 25% are halogenated alkaloids. This is not surprising since nitrogen-containing pyrroles, indoles, carbolines, tryptamines, tyrosines, and tyramines are excellent platforms for biohalogenation, particularly in the marine environment where both chloride and bromide are plentiful for biooxidation and subsequent incorporation into these electron-rich substrates. This review presents the occurrence of all halogenated alkaloids, with the exception of marine bromotyrosines where coverage begins where it left off in volume 61 of The Alkaloids. Whereas the biological activity of these extraordinary compounds is briefly cited for some examples, a future volume of The Alkaloids will present full coverage of this topic and will also include selected syntheses of halogenated alkaloids. Natural organohalogens of all types, especially marine and terrestrial halogenated alkaloids, comprise a rapidly expanding class of natural products, in many cases expressing powerful biological activity. This enormous proliferation has several origins: (1) a revitalization of natural product research in a search for new drugs, (2) improved compound characterization methods (multidimensional NMR, high-resolution mass spectrometry), (3) specific enzyme-based and other biological assays, (4) sophisticated collection methods (SCUBA and remote submersibles for deep ocean marine collections), (5) new separation and purification techniques (HPLC and countercurrent separation), (6) a greater appreciation of traditional folk medicine and ethobotany, and (7) marine bacteria and fungi as novel sources of natural products. Halogenated alkaloids are truly omnipresent in the environment. Indeed, one compound, Q1 (234), is ubiquitous in the marine food web and is found in the Inuit from their diet of whale blubber. Given the fact that of the 500,000 estimated marine organisms--which are the source of most halogenated alkaloids--only a small percentage have been investigated for their chemical content, it is certain that myriad new halogenated alkaloids are awaiting discovery. For example, it is estimated that nearly 4000 species of bryozoans have not been examined for their chemical content. The few species that have been studied contain some extraordinary halogenated alkaloids, such as hinckdentine A (610) and the chartellines (611-613). Of the estimated 1.5 million species of fungi, secondary metabolites have been characterized from only 5000 species. The future seems bright for the collector of halogenated alkaloids!" @default.
- W2951932018 created "2019-06-27" @default.
- W2951932018 creator A5049245360 @default.
- W2951932018 date "2013-02-05" @default.
- W2951932018 modified "2023-09-27" @default.
- W2951932018 title "ChemInform Abstract: Occurrence of Halogenated Alkaloids" @default.
- W2951932018 doi "https://doi.org/10.1002/chin.201306181" @default.
- W2951932018 hasPublicationYear "2013" @default.
- W2951932018 type Work @default.
- W2951932018 sameAs 2951932018 @default.
- W2951932018 citedByCount "0" @default.
- W2951932018 crossrefType "journal-article" @default.
- W2951932018 hasAuthorship W2951932018A5049245360 @default.
- W2951932018 hasConcept C107872376 @default.
- W2951932018 hasConcept C178790620 @default.
- W2951932018 hasConcept C185592680 @default.
- W2951932018 hasConcept C2779396153 @default.
- W2951932018 hasConceptScore W2951932018C107872376 @default.
- W2951932018 hasConceptScore W2951932018C178790620 @default.
- W2951932018 hasConceptScore W2951932018C185592680 @default.
- W2951932018 hasConceptScore W2951932018C2779396153 @default.
- W2951932018 hasLocation W29519320181 @default.
- W2951932018 hasOpenAccess W2951932018 @default.
- W2951932018 hasPrimaryLocation W29519320181 @default.
- W2951932018 hasRelatedWork W1022120720 @default.
- W2951932018 hasRelatedWork W121756344 @default.
- W2951932018 hasRelatedWork W1977468235 @default.
- W2951932018 hasRelatedWork W2007359966 @default.
- W2951932018 hasRelatedWork W2032989782 @default.
- W2951932018 hasRelatedWork W2071323876 @default.
- W2951932018 hasRelatedWork W2097039666 @default.
- W2951932018 hasRelatedWork W2409973216 @default.
- W2951932018 hasRelatedWork W2552827599 @default.
- W2951932018 hasRelatedWork W26821528 @default.
- W2951932018 hasRelatedWork W2901377678 @default.
- W2951932018 hasRelatedWork W2901939272 @default.
- W2951932018 hasRelatedWork W2912585846 @default.
- W2951932018 hasRelatedWork W2949516035 @default.
- W2951932018 hasRelatedWork W2952098780 @default.
- W2951932018 hasRelatedWork W3000680906 @default.
- W2951932018 hasRelatedWork W3121196093 @default.
- W2951932018 hasRelatedWork W3158119859 @default.
- W2951932018 hasRelatedWork W40124954 @default.
- W2951932018 hasRelatedWork W2189144949 @default.
- W2951932018 isParatext "false" @default.
- W2951932018 isRetracted "false" @default.
- W2951932018 magId "2951932018" @default.
- W2951932018 workType "article" @default.