Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951943247> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2951943247 endingPage "5551" @default.
- W2951943247 startingPage "5551" @default.
- W2951943247 abstract "5551 Purpose: Recent clinical trials suggest a survival advantage for adjuvant chemotherapy in non-small cell lung cancer (NSCLC). This study’s aim is to identify genes associated with NSCLC recurrence in patients not receiving adjuvant chemotherapy. Experimental design: Banked NSCLC tumors of patients who underwent resection of stage Ia-IIIb disease were identified. Patients were stratified into two groups: recurrent (R, n=11) or non-recurrent (NR, n=16) at two years following surgery. Microarray profiling and Cox multivariate analysis were performed. Results: Unsupervised clustering analysis using 51 probe sets separated the R and NR tumors. The CYP3A5 gene exhibited the greatest differential expression and was increased 18.7-fold in Group R (P=0.00013). Risk of NSCLC recurrence was highly associated with the ln of CYP3A5 gene expression (hazard ratio [HR] 2.80; 95% CI 1.58, 4.95; P=0.0004) and higher CYP3A5 was associated with a shorter time to recurrence (TTR). Older age at the time of surgery was marginally associated with decreased recurrence (HR 0.96; 95% CI 0.92, 1.00; P=0.033), while smoking history, race and sex were not significant. CYP3A5 was predominantly expressed in the NSCLC tumor epithelium. siRNA knock down of CYP3A5 in the A549 and H358 NSCLC lines inhibits proliferation. A potential mechanism of CYP3A5 in NSCLC progression involves CYP3A5 conversion of arachidonate to epoxyeicosatrienoic acids (EET’s), which are mitogenic for NSCLC lines under conditions of hypoxia. Conclusion: CYP3A5 gene expression is correlated with NSCLC recurrence and synthesizes EET, which promotes NSCLC growth. While the mechanisms of CYP3A5 in NSCLC recurrence remain to be identified, they may involve, in part, its epoxygenase activity." @default.
- W2951943247 created "2019-06-27" @default.
- W2951943247 creator A5006346528 @default.
- W2951943247 creator A5007007052 @default.
- W2951943247 creator A5012831120 @default.
- W2951943247 creator A5020452921 @default.
- W2951943247 creator A5041038506 @default.
- W2951943247 creator A5043430500 @default.
- W2951943247 creator A5044635265 @default.
- W2951943247 creator A5050885519 @default.
- W2951943247 creator A5058946252 @default.
- W2951943247 creator A5066000875 @default.
- W2951943247 creator A5066899337 @default.
- W2951943247 creator A5079384190 @default.
- W2951943247 creator A5080385299 @default.
- W2951943247 creator A5089679708 @default.
- W2951943247 date "2008-05-01" @default.
- W2951943247 modified "2023-09-27" @default.
- W2951943247 title "CYP3A5 gene expression is associated with early recurrence of non-small cell lung cancer" @default.
- W2951943247 hasPublicationYear "2008" @default.
- W2951943247 type Work @default.
- W2951943247 sameAs 2951943247 @default.
- W2951943247 citedByCount "0" @default.
- W2951943247 crossrefType "journal-article" @default.
- W2951943247 hasAuthorship W2951943247A5006346528 @default.
- W2951943247 hasAuthorship W2951943247A5007007052 @default.
- W2951943247 hasAuthorship W2951943247A5012831120 @default.
- W2951943247 hasAuthorship W2951943247A5020452921 @default.
- W2951943247 hasAuthorship W2951943247A5041038506 @default.
- W2951943247 hasAuthorship W2951943247A5043430500 @default.
- W2951943247 hasAuthorship W2951943247A5044635265 @default.
- W2951943247 hasAuthorship W2951943247A5050885519 @default.
- W2951943247 hasAuthorship W2951943247A5058946252 @default.
- W2951943247 hasAuthorship W2951943247A5066000875 @default.
- W2951943247 hasAuthorship W2951943247A5066899337 @default.
- W2951943247 hasAuthorship W2951943247A5079384190 @default.
- W2951943247 hasAuthorship W2951943247A5080385299 @default.
- W2951943247 hasAuthorship W2951943247A5089679708 @default.
- W2951943247 hasConcept C104317684 @default.
- W2951943247 hasConcept C126322002 @default.
- W2951943247 hasConcept C135763542 @default.
- W2951943247 hasConcept C143998085 @default.
- W2951943247 hasConcept C150194340 @default.
- W2951943247 hasConcept C18431079 @default.
- W2951943247 hasConcept C207103383 @default.
- W2951943247 hasConcept C2776256026 @default.
- W2951943247 hasConcept C2776694085 @default.
- W2951943247 hasConcept C44249647 @default.
- W2951943247 hasConcept C502942594 @default.
- W2951943247 hasConcept C55493867 @default.
- W2951943247 hasConcept C71924100 @default.
- W2951943247 hasConcept C86803240 @default.
- W2951943247 hasConcept C92137452 @default.
- W2951943247 hasConceptScore W2951943247C104317684 @default.
- W2951943247 hasConceptScore W2951943247C126322002 @default.
- W2951943247 hasConceptScore W2951943247C135763542 @default.
- W2951943247 hasConceptScore W2951943247C143998085 @default.
- W2951943247 hasConceptScore W2951943247C150194340 @default.
- W2951943247 hasConceptScore W2951943247C18431079 @default.
- W2951943247 hasConceptScore W2951943247C207103383 @default.
- W2951943247 hasConceptScore W2951943247C2776256026 @default.
- W2951943247 hasConceptScore W2951943247C2776694085 @default.
- W2951943247 hasConceptScore W2951943247C44249647 @default.
- W2951943247 hasConceptScore W2951943247C502942594 @default.
- W2951943247 hasConceptScore W2951943247C55493867 @default.
- W2951943247 hasConceptScore W2951943247C71924100 @default.
- W2951943247 hasConceptScore W2951943247C86803240 @default.
- W2951943247 hasConceptScore W2951943247C92137452 @default.
- W2951943247 hasLocation W29519432471 @default.
- W2951943247 hasOpenAccess W2951943247 @default.
- W2951943247 hasPrimaryLocation W29519432471 @default.
- W2951943247 hasRelatedWork W1990837461 @default.
- W2951943247 hasRelatedWork W2033445993 @default.
- W2951943247 hasRelatedWork W2150787678 @default.
- W2951943247 hasRelatedWork W2352520013 @default.
- W2951943247 hasRelatedWork W2355163952 @default.
- W2951943247 hasRelatedWork W2364378486 @default.
- W2951943247 hasRelatedWork W2368246504 @default.
- W2951943247 hasRelatedWork W2379827089 @default.
- W2951943247 hasRelatedWork W2414768323 @default.
- W2951943247 hasRelatedWork W2508053938 @default.
- W2951943247 hasRelatedWork W2613270272 @default.
- W2951943247 hasRelatedWork W2795105142 @default.
- W2951943247 hasRelatedWork W2913876929 @default.
- W2951943247 hasRelatedWork W3018253043 @default.
- W2951943247 hasRelatedWork W3031590958 @default.
- W2951943247 hasRelatedWork W3123434641 @default.
- W2951943247 hasRelatedWork W3142843053 @default.
- W2951943247 hasRelatedWork W3149988215 @default.
- W2951943247 hasRelatedWork W3201047071 @default.
- W2951943247 hasRelatedWork W1957633878 @default.
- W2951943247 hasVolume "68" @default.
- W2951943247 isParatext "false" @default.
- W2951943247 isRetracted "false" @default.
- W2951943247 magId "2951943247" @default.
- W2951943247 workType "article" @default.