Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951960109> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2951960109 abstract "SLE patients suffered from morbidities resembled the natural aging process, suggesting chronic inflammation in SLE is correlated to premature immune senescence. However, understanding of immune senescence in SLE is not well established. The purpose of this study was to investigate the association of CD4+ and CD8+ T cells senescence markers of end differentiated T cell (CD28-), memory T cell (CD45RO+) and cytokines correlated to inflammaging (IL-2, and IFN-γ) among 61 SLE subjects aged 16-56 years. We measured the percentages of T cell senescence by flow cytometric analysis. Serum IL-2 and IFN-γ were measured by ELISA. Among 61 subjects, percentages of SLE subjects with increased senescence cells ranges from 3.2-58.3%. There was a positive correlation between the percentage of senescent T cells and serum IFN-γ (CD4+CD45RO+; p = 0.003, r = 0.453; CD8+CD45RO+; p = 0.045, r = 0.284; and CD4+CD28-; p = 0.029, r = 0.257) and negative correlation for the percentage of senescent T cells and serum IL-2 (CD4+CD28-; p = 0.014, r = −0384; CD8+CD28-; p = 0.012, r = −0394; CD4+CD45RO+; p = 0.023, r = −0.322; and CD8+CD45RO+; p = 0.017, r = −0.335). This study confirms the role of immune senescence in SLE pathogenesis, particularly in regard to the observed loss of CD28 and increased percentages of CD45RO expression from both CD8+ and CD4+ T cells. We also found the inflammaging process in SLE was correlated to T cell senescence. Studies of immune senescence might provide new opportunities for better understanding of SLE pathogenesis." @default.
- W2951960109 created "2019-06-27" @default.
- W2951960109 creator A5020213914 @default.
- W2951960109 creator A5043884670 @default.
- W2951960109 creator A5052426511 @default.
- W2951960109 creator A5070030992 @default.
- W2951960109 date "2019-01-01" @default.
- W2951960109 modified "2023-10-17" @default.
- W2951960109 title "T cell senescence and its correlation to inflammaging process of patients with systemic lupus erythematosus" @default.
- W2951960109 cites W127589520 @default.
- W2951960109 cites W1544192636 @default.
- W2951960109 cites W1572743872 @default.
- W2951960109 cites W1970350730 @default.
- W2951960109 cites W1980579670 @default.
- W2951960109 cites W1992396801 @default.
- W2951960109 cites W1995828329 @default.
- W2951960109 cites W2005458272 @default.
- W2951960109 cites W2025551721 @default.
- W2951960109 cites W2037638393 @default.
- W2951960109 cites W2043554990 @default.
- W2951960109 cites W2077450385 @default.
- W2951960109 cites W2085012741 @default.
- W2951960109 cites W2119896120 @default.
- W2951960109 cites W2129155846 @default.
- W2951960109 cites W2146087105 @default.
- W2951960109 cites W2153127464 @default.
- W2951960109 cites W2171222083 @default.
- W2951960109 cites W2177939130 @default.
- W2951960109 cites W2215279754 @default.
- W2951960109 cites W2307755391 @default.
- W2951960109 cites W2325522540 @default.
- W2951960109 cites W24438689 @default.
- W2951960109 cites W2551404503 @default.
- W2951960109 cites W2582318172 @default.
- W2951960109 cites W2739990827 @default.
- W2951960109 cites W4230861862 @default.
- W2951960109 cites W4253613523 @default.
- W2951960109 doi "https://doi.org/10.1063/1.5110006" @default.
- W2951960109 hasPublicationYear "2019" @default.
- W2951960109 type Work @default.
- W2951960109 sameAs 2951960109 @default.
- W2951960109 citedByCount "0" @default.
- W2951960109 crossrefType "proceedings-article" @default.
- W2951960109 hasAuthorship W2951960109A5020213914 @default.
- W2951960109 hasAuthorship W2951960109A5043884670 @default.
- W2951960109 hasAuthorship W2951960109A5052426511 @default.
- W2951960109 hasAuthorship W2951960109A5070030992 @default.
- W2951960109 hasConcept C126322002 @default.
- W2951960109 hasConcept C134018914 @default.
- W2951960109 hasConcept C148125776 @default.
- W2951960109 hasConcept C167672396 @default.
- W2951960109 hasConcept C203014093 @default.
- W2951960109 hasConcept C2776090121 @default.
- W2951960109 hasConcept C2776914184 @default.
- W2951960109 hasConcept C2779056147 @default.
- W2951960109 hasConcept C2780942790 @default.
- W2951960109 hasConcept C500499127 @default.
- W2951960109 hasConcept C522857546 @default.
- W2951960109 hasConcept C553184892 @default.
- W2951960109 hasConcept C71924100 @default.
- W2951960109 hasConcept C86803240 @default.
- W2951960109 hasConcept C8891405 @default.
- W2951960109 hasConceptScore W2951960109C126322002 @default.
- W2951960109 hasConceptScore W2951960109C134018914 @default.
- W2951960109 hasConceptScore W2951960109C148125776 @default.
- W2951960109 hasConceptScore W2951960109C167672396 @default.
- W2951960109 hasConceptScore W2951960109C203014093 @default.
- W2951960109 hasConceptScore W2951960109C2776090121 @default.
- W2951960109 hasConceptScore W2951960109C2776914184 @default.
- W2951960109 hasConceptScore W2951960109C2779056147 @default.
- W2951960109 hasConceptScore W2951960109C2780942790 @default.
- W2951960109 hasConceptScore W2951960109C500499127 @default.
- W2951960109 hasConceptScore W2951960109C522857546 @default.
- W2951960109 hasConceptScore W2951960109C553184892 @default.
- W2951960109 hasConceptScore W2951960109C71924100 @default.
- W2951960109 hasConceptScore W2951960109C86803240 @default.
- W2951960109 hasConceptScore W2951960109C8891405 @default.
- W2951960109 hasLocation W29519601091 @default.
- W2951960109 hasOpenAccess W2951960109 @default.
- W2951960109 hasPrimaryLocation W29519601091 @default.
- W2951960109 hasRelatedWork W1969189285 @default.
- W2951960109 hasRelatedWork W1989985918 @default.
- W2951960109 hasRelatedWork W1992542379 @default.
- W2951960109 hasRelatedWork W2043402731 @default.
- W2951960109 hasRelatedWork W2073812334 @default.
- W2951960109 hasRelatedWork W2115516753 @default.
- W2951960109 hasRelatedWork W2137924926 @default.
- W2951960109 hasRelatedWork W2948097970 @default.
- W2951960109 hasRelatedWork W2972520383 @default.
- W2951960109 hasRelatedWork W3161778279 @default.
- W2951960109 isParatext "false" @default.
- W2951960109 isRetracted "false" @default.
- W2951960109 magId "2951960109" @default.
- W2951960109 workType "article" @default.