Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951969951> ?p ?o ?g. }
- W2951969951 abstract "Abstract Male gametes are generated through a specialised differentiation pathway involving a series of developmental transitions that are poorly characterised at the molecular level. Here, we use droplet-based single-cell RNA-Sequencing to profile spermatogenesis in adult animals and at multiple stages during juvenile development. By exploiting the first wave of spermatogenesis, we both precisely stage germ cell development and enrich for rare somatic cell-types and spermatogonia. To capture the full complexity of spermatogenesis including cells that have low transcriptional activity, we apply a statistical tool that identifies previously uncharacterised populations of leptotene and zygotene spermatocytes. Focusing on post-meiotic events, we characterise the temporal dynamics of X chromosome re-activation and profile the associated chromatin state using CUT&RUN. This identifies a set of genes strongly repressed by H3K9me3 in spermatocytes, which then undergo extensive chromatin remodelling post-meiosis, thus acquiring an active chromatin state and spermatid-specific expression." @default.
- W2951969951 created "2019-06-27" @default.
- W2951969951 creator A5004833953 @default.
- W2951969951 creator A5026527049 @default.
- W2951969951 creator A5042376614 @default.
- W2951969951 creator A5049527280 @default.
- W2951969951 creator A5056137343 @default.
- W2951969951 date "2019-03-19" @default.
- W2951969951 modified "2023-10-12" @default.
- W2951969951 title "Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis" @default.
- W2951969951 cites W1500437458 @default.
- W2951969951 cites W1521702495 @default.
- W2951969951 cites W1606401780 @default.
- W2951969951 cites W1964480889 @default.
- W2951969951 cites W1968421891 @default.
- W2951969951 cites W1975334494 @default.
- W2951969951 cites W1980912680 @default.
- W2951969951 cites W1981376185 @default.
- W2951969951 cites W1984883254 @default.
- W2951969951 cites W1985993046 @default.
- W2951969951 cites W1993446240 @default.
- W2951969951 cites W1994950146 @default.
- W2951969951 cites W1996327813 @default.
- W2951969951 cites W2002393431 @default.
- W2951969951 cites W2007074774 @default.
- W2951969951 cites W2021864916 @default.
- W2951969951 cites W2022119516 @default.
- W2951969951 cites W2033623501 @default.
- W2951969951 cites W2046275054 @default.
- W2951969951 cites W2050926557 @default.
- W2951969951 cites W2060197495 @default.
- W2951969951 cites W2063292930 @default.
- W2951969951 cites W2063638091 @default.
- W2951969951 cites W2064446194 @default.
- W2951969951 cites W2071709406 @default.
- W2951969951 cites W2075977131 @default.
- W2951969951 cites W2077313738 @default.
- W2951969951 cites W2086410320 @default.
- W2951969951 cites W2091028885 @default.
- W2951969951 cites W2092158511 @default.
- W2951969951 cites W2096530329 @default.
- W2951969951 cites W2097323692 @default.
- W2951969951 cites W2102212449 @default.
- W2951969951 cites W2104359745 @default.
- W2951969951 cites W2109890799 @default.
- W2951969951 cites W2114104545 @default.
- W2951969951 cites W2127911142 @default.
- W2951969951 cites W2131681506 @default.
- W2951969951 cites W2133894023 @default.
- W2951969951 cites W2134526812 @default.
- W2951969951 cites W2134710117 @default.
- W2951969951 cites W2135937351 @default.
- W2951969951 cites W2139096635 @default.
- W2951969951 cites W2144746162 @default.
- W2951969951 cites W2145380712 @default.
- W2951969951 cites W2146636202 @default.
- W2951969951 cites W2147826510 @default.
- W2951969951 cites W2150335729 @default.
- W2951969951 cites W2154715879 @default.
- W2951969951 cites W2160762623 @default.
- W2951969951 cites W2169456326 @default.
- W2951969951 cites W2171960324 @default.
- W2951969951 cites W2179438025 @default.
- W2951969951 cites W2261235911 @default.
- W2951969951 cites W2285285644 @default.
- W2951969951 cites W2343956310 @default.
- W2951969951 cites W2465316128 @default.
- W2951969951 cites W2516455020 @default.
- W2951969951 cites W2539876887 @default.
- W2951969951 cites W2540833380 @default.
- W2951969951 cites W2554405032 @default.
- W2951969951 cites W2569242246 @default.
- W2951969951 cites W2582005133 @default.
- W2951969951 cites W2604767392 @default.
- W2951969951 cites W2757704052 @default.
- W2951969951 cites W2768062840 @default.
- W2951969951 cites W2783760208 @default.
- W2951969951 cites W2788760640 @default.
- W2951969951 cites W2794521141 @default.
- W2951969951 cites W2796221392 @default.
- W2951969951 cites W2799935500 @default.
- W2951969951 cites W2806983506 @default.
- W2951969951 cites W2883409661 @default.
- W2951969951 cites W2887103892 @default.
- W2951969951 cites W2888403713 @default.
- W2951969951 cites W2889446142 @default.
- W2951969951 cites W2896156331 @default.
- W2951969951 cites W2899394207 @default.
- W2951969951 cites W2900354600 @default.
- W2951969951 cites W2940256315 @default.
- W2951969951 cites W2949275240 @default.
- W2951969951 cites W2951506174 @default.
- W2951969951 cites W2954018630 @default.
- W2951969951 cites W2978619447 @default.
- W2951969951 cites W3000826358 @default.
- W2951969951 cites W3101664610 @default.
- W2951969951 cites W4236735298 @default.
- W2951969951 cites W4251002338 @default.
- W2951969951 cites W2587143208 @default.
- W2951969951 doi "https://doi.org/10.1038/s41467-019-09182-1" @default.