FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951972632> ?p ?o ?g. }

• W2951972632 endingPage "296" @default.
• W2951972632 startingPage "288" @default.
• W2951972632 abstract "Cilostazol is a selective inhibitor of phosphodiesterase III (PDE III), which is prescribed for patients with peripheral arterial disease, especially intermittent claudication. The purpose of the study was to investigate the pharmacokinetic (PK) of cilostazol and its metabolites on the immediate (IR) formulation of cilostazol in healthy Korean male volunteers by population PK modeling analysis implemented using NONMEM software.A 2 × 2 crossover study comparing multiple oral doses of IR and SR formulations of cilostazol were conducted. Serial plasma concentrations of cilostazol and its active metabolites were used in this analysis.The PK was best depicted by one-compartment model, with absorption kinetics of cilostazol having mixed first- and zero-order kinetics with a time delay at the beginning of absorption. The introduction of interoccasion variabilities into zero-order (D1), first-order (Ka), and relative bioavailability (F1) significantly improved the model fit, and total body water (TBW) was identified as a significant covariate positively affecting the clearance of cilostazol. The model validation suggested that the model constructed in this study predicted the plasma concentration of cilostazol and its two active metabolites reasonably well.The PK model we developed explored the PK characteristics of cilostazol in Korean male subjects, and may be useful for identifying optimal individual dosing regimens of cilostazol." @default.
• W2951972632 created "2019-06-27" @default.
• W2951972632 creator A5007426315 @default.
• W2951972632 creator A5012863228 @default.
• W2951972632 creator A5021252915 @default.
• W2951972632 creator A5027984567 @default.
• W2951972632 creator A5045996360 @default.
• W2951972632 creator A5058329575 @default.
• W2951972632 creator A5065283669 @default.
• W2951972632 creator A5081445503 @default.
• W2951972632 creator A5085479819 @default.
• W2951972632 date "2019-07-03" @default.
• W2951972632 modified "2023-09-30" @default.
• W2951972632 title "Pharmacokinetic modeling analysis of cilostazol and its active metabolites (OPC-13015 and OPC-13213) after multiple oral doses of cilostazol in healthy Korean volunteers" @default.
• W2951972632 cites W186368821 @default.
• W2951972632 cites W1957229693 @default.
• W2951972632 cites W1997849419 @default.
• W2951972632 cites W2000104976 @default.
• W2951972632 cites W2002893478 @default.
• W2951972632 cites W2017624698 @default.
• W2951972632 cites W2023327445 @default.
• W2951972632 cites W2027387528 @default.
• W2951972632 cites W2027538725 @default.
• W2951972632 cites W2037506783 @default.
• W2951972632 cites W2047644852 @default.
• W2951972632 cites W2057108698 @default.
• W2951972632 cites W2077405191 @default.
• W2951972632 cites W2081043307 @default.
• W2951972632 cites W2100255765 @default.
• W2951972632 cites W2133501611 @default.
• W2951972632 cites W2140161831 @default.
• W2951972632 cites W2339818322 @default.
• W2951972632 cites W2883557648 @default.
• W2951972632 doi "https://doi.org/10.1080/00498254.2019.1629042" @default.
• W2951972632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31181990" @default.
• W2951972632 hasPublicationYear "2019" @default.
• W2951972632 type Work @default.
• W2951972632 sameAs 2951972632 @default.
• W2951972632 citedByCount "3" @default.
• W2951972632 countsByYear W29519726322021 @default.
• W2951972632 crossrefType "journal-article" @default.
• W2951972632 hasAuthorship W2951972632A5007426315 @default.
• W2951972632 hasAuthorship W2951972632A5012863228 @default.
• W2951972632 hasAuthorship W2951972632A5021252915 @default.
• W2951972632 hasAuthorship W2951972632A5027984567 @default.
• W2951972632 hasAuthorship W2951972632A5045996360 @default.
• W2951972632 hasAuthorship W2951972632A5058329575 @default.
• W2951972632 hasAuthorship W2951972632A5065283669 @default.
• W2951972632 hasAuthorship W2951972632A5081445503 @default.
• W2951972632 hasAuthorship W2951972632A5085479819 @default.
• W2951972632 hasConcept C112705442 @default.
• W2951972632 hasConcept C126322002 @default.
• W2951972632 hasConcept C142724271 @default.
• W2951972632 hasConcept C181389837 @default.
• W2951972632 hasConcept C204787440 @default.
• W2951972632 hasConcept C27081682 @default.
• W2951972632 hasConcept C2776239304 @default.
• W2951972632 hasConcept C2777466421 @default.
• W2951972632 hasConcept C2777628954 @default.
• W2951972632 hasConcept C2779820409 @default.
• W2951972632 hasConcept C2779881954 @default.
• W2951972632 hasConcept C2908647359 @default.
• W2951972632 hasConcept C3018348675 @default.
• W2951972632 hasConcept C71924100 @default.
• W2951972632 hasConcept C87813604 @default.
• W2951972632 hasConcept C98274493 @default.
• W2951972632 hasConcept C99454951 @default.
• W2951972632 hasConceptScore W2951972632C112705442 @default.
• W2951972632 hasConceptScore W2951972632C126322002 @default.
• W2951972632 hasConceptScore W2951972632C142724271 @default.
• W2951972632 hasConceptScore W2951972632C181389837 @default.
• W2951972632 hasConceptScore W2951972632C204787440 @default.
• W2951972632 hasConceptScore W2951972632C27081682 @default.
• W2951972632 hasConceptScore W2951972632C2776239304 @default.
• W2951972632 hasConceptScore W2951972632C2777466421 @default.
• W2951972632 hasConceptScore W2951972632C2777628954 @default.
• W2951972632 hasConceptScore W2951972632C2779820409 @default.
• W2951972632 hasConceptScore W2951972632C2779881954 @default.
• W2951972632 hasConceptScore W2951972632C2908647359 @default.
• W2951972632 hasConceptScore W2951972632C3018348675 @default.
• W2951972632 hasConceptScore W2951972632C71924100 @default.
• W2951972632 hasConceptScore W2951972632C87813604 @default.
• W2951972632 hasConceptScore W2951972632C98274493 @default.
• W2951972632 hasConceptScore W2951972632C99454951 @default.
• W2951972632 hasIssue "3" @default.
• W2951972632 hasLocation W29519726321 @default.
• W2951972632 hasLocation W29519726322 @default.
• W2951972632 hasOpenAccess W2951972632 @default.
• W2951972632 hasPrimaryLocation W29519726321 @default.
• W2951972632 hasRelatedWork W1555144605 @default.
• W2951972632 hasRelatedWork W1970245702 @default.
• W2951972632 hasRelatedWork W1970331292 @default.
• W2951972632 hasRelatedWork W1984317973 @default.
• W2951972632 hasRelatedWork W2080955156 @default.
• W2951972632 hasRelatedWork W2379311614 @default.
• W2951972632 hasRelatedWork W2389037049 @default.
• W2951972632 hasRelatedWork W2400119402 @default.
• W2951972632 hasRelatedWork W2606334551 @default.

• next