FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951982561> ?p ?o ?g. }

• W2951982561 abstract "Radiation treatment to the regional nodes results in an improvement in survival in breast cancer according to a meta-analysis of randomized trials. However, different volumes were targeted in these studies: breast or chestwall only (WBI/CWI), inclusion of the medial supraclavicular region and axillary apex (MS + WBI/CWI) or additional inclusion of the internal mammary chain (IM + MS + WBI/CWI). The benefit of treating the medial supraclavicular region and axillary apex compared to tangential breast or chestwall irradiation only remains unclear.A literature search was conducted identifying trials for adjuvant radiation volumes in nodal irradiation after breast surgery and axillary treatment. Events and effect sizes were extracted from the publications for the endpoints of overall survival (OS), breast cancer-specific survival (BCSS), disease-free survival (DFS), distant metastasis-free survival (DMFS) and loco-regional control (LRC). A network meta-analysis was performed using MetaXL V5.3 with the inverse variance heterogeneity model.We found two randomized studies (n = 5836) comparing comprehensive nodal irradiation to sole breast treatment as well as one randomized (n = 1407) and one prospective cohort study (n = 3377) analysing the additional treatment of the internal mammary chain against sole local and supraclavicular and axillary apex radiation. Compared to WBI/CWI alone the treatment of IM + MS + WBI/CWI (HR = 0.88; CI:0.78-0.99; p = 0.036) results in improved OS unlike MS + WBI/CWI (HR = 0.99; CI:0.86-1.14; p = 0,89). These results are confirmed in BCSS: IM + MS + WBI/CWI (HR = 0.82; CI:0.72-0.92; p = 0.002) and MS + WBI/CWI (HR = 0.96; CI:0.79-1.18; p = 0.69). PFS is significantly improved with the treatment of MS + WBI/CWI (OR = 0.83; CI:0.71-0.97; p = 0.019). Both nodal treatment volumes improve LRC (MS + WBI/CWI OR = 0.74; CI:0.62-0.87; p = 0.004 and IM + MS + WBI/CWI OR = 0.60; CI:0.43-0.86; p < 0,001). Yet only the internal mammary nodes provide a benefit in DMFS (MS + WBI/CWI HR = 0.97; CI:0.81-1.16; p = 0.74 and IM + MS + WBI/CWI HR = 0.84; CI:0.75-0.94; p = 0.002).Expanding the radiation field to the axillary apex and supraclavicular nodes after axillary node dissection reduced loco-regional recurrences without improvement in overall and cancer-specific survival. A prolongation in survival due to regional nodal irradiation is achieved when the internal mammary chain is included. This derives from a reduction in distant metastasis." @default.
• W2951982561 created "2019-06-27" @default.
• W2951982561 creator A5004434507 @default.
• W2951982561 creator A5017329335 @default.
• W2951982561 creator A5029041045 @default.
• W2951982561 creator A5058147730 @default.
• W2951982561 creator A5059175252 @default.
• W2951982561 creator A5060729994 @default.
• W2951982561 creator A5061577177 @default.
• W2951982561 creator A5073827670 @default.
• W2951982561 date "2019-06-11" @default.
• W2951982561 modified "2023-10-12" @default.
• W2951982561 title "Which target volume should be considered when irradiating the regional nodes in breast cancer? Results of a network-meta-analysis" @default.
• W2951982561 cites W1770259999 @default.
• W2951982561 cites W1883643540 @default.
• W2951982561 cites W1984129028 @default.
• W2951982561 cites W1986559249 @default.
• W2951982561 cites W1986993149 @default.
• W2951982561 cites W1989817171 @default.
• W2951982561 cites W1997153807 @default.
• W2951982561 cites W2019297220 @default.
• W2951982561 cites W2034163082 @default.
• W2951982561 cites W2048102172 @default.
• W2951982561 cites W2050757640 @default.
• W2951982561 cites W2061354674 @default.
• W2951982561 cites W2067420088 @default.
• W2951982561 cites W2075642745 @default.
• W2951982561 cites W2082280032 @default.
• W2951982561 cites W2087263485 @default.
• W2951982561 cites W2103729178 @default.
• W2951982561 cites W2103952460 @default.
• W2951982561 cites W2114349652 @default.
• W2951982561 cites W2123074327 @default.
• W2951982561 cites W2129825983 @default.
• W2951982561 cites W2133865595 @default.
• W2951982561 cites W2144293828 @default.
• W2951982561 cites W2154375587 @default.
• W2951982561 cites W2156003808 @default.
• W2951982561 cites W2156098321 @default.
• W2951982561 cites W2176010689 @default.
• W2951982561 cites W2205503125 @default.
• W2951982561 cites W2345239323 @default.
• W2951982561 cites W2566074209 @default.
• W2951982561 cites W2574924994 @default.
• W2951982561 cites W2579017745 @default.
• W2951982561 cites W2742020913 @default.
• W2951982561 cites W2754855139 @default.
• W2951982561 cites W2795685622 @default.
• W2951982561 cites W2800678179 @default.
• W2951982561 cites W2801448601 @default.
• W2951982561 cites W2803349380 @default.
• W2951982561 cites W2805228664 @default.
• W2951982561 cites W2883962331 @default.
• W2951982561 cites W2888575027 @default.
• W2951982561 cites W2895708926 @default.
• W2951982561 cites W2904192497 @default.
• W2951982561 cites W2991792334 @default.
• W2951982561 cites W3144879707 @default.
• W2951982561 cites W4235461667 @default.
• W2951982561 cites W993406450 @default.
• W2951982561 doi "https://doi.org/10.1186/s13014-019-1280-6" @default.
• W2951982561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6558843" @default.
• W2951982561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31186015" @default.
• W2951982561 hasPublicationYear "2019" @default.
• W2951982561 type Work @default.
• W2951982561 sameAs 2951982561 @default.
• W2951982561 citedByCount "14" @default.
• W2951982561 countsByYear W29519825612020 @default.
• W2951982561 countsByYear W29519825612021 @default.
• W2951982561 countsByYear W29519825612022 @default.
• W2951982561 countsByYear W29519825612023 @default.
• W2951982561 crossrefType "journal-article" @default.
• W2951982561 hasAuthorship W2951982561A5004434507 @default.
• W2951982561 hasAuthorship W2951982561A5017329335 @default.
• W2951982561 hasAuthorship W2951982561A5029041045 @default.
• W2951982561 hasAuthorship W2951982561A5058147730 @default.
• W2951982561 hasAuthorship W2951982561A5059175252 @default.
• W2951982561 hasAuthorship W2951982561A5060729994 @default.
• W2951982561 hasAuthorship W2951982561A5061577177 @default.
• W2951982561 hasAuthorship W2951982561A5073827670 @default.
• W2951982561 hasBestOaLocation W29519825611 @default.
• W2951982561 hasConcept C105702510 @default.
• W2951982561 hasConcept C121608353 @default.
• W2951982561 hasConcept C126322002 @default.
• W2951982561 hasConcept C143998085 @default.
• W2951982561 hasConcept C168563851 @default.
• W2951982561 hasConcept C509974204 @default.
• W2951982561 hasConcept C530470458 @default.
• W2951982561 hasConcept C67139541 @default.
• W2951982561 hasConcept C71924100 @default.
• W2951982561 hasConcept C95190672 @default.
• W2951982561 hasConceptScore W2951982561C105702510 @default.
• W2951982561 hasConceptScore W2951982561C121608353 @default.
• W2951982561 hasConceptScore W2951982561C126322002 @default.
• W2951982561 hasConceptScore W2951982561C143998085 @default.
• W2951982561 hasConceptScore W2951982561C168563851 @default.
• W2951982561 hasConceptScore W2951982561C509974204 @default.
• W2951982561 hasConceptScore W2951982561C530470458 @default.
• W2951982561 hasConceptScore W2951982561C67139541 @default.
• W2951982561 hasConceptScore W2951982561C71924100 @default.

• next