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• W2952001657 startingPage "375" @default.
• W2952001657 abstract "Abstract Forward genetics determines the function of genes underlying trait variation by identifying the change in DNA responsible for changes in phenotype. Detecting phenotypically-relevant variation outside protein coding sequences and distinguishing this from neutral variants is not trivial; partly because the mechanisms by which DNA polymorphisms in the intergenic regions affect gene regulation are poorly understood. Here we utilized a dominant genetic reporter to investigate the effect of cis and trans-acting regulatory variation. We performed a forward genetic screen for natural variation that suppressed or enhanced the semi-dominant mutant allele Oy1-N1989, encoding the magnesium chelatase subunit I of maize. This mutant permits rapid phenotyping of leaf color as a reporter for chlorophyll accumulation, and mapping of natural variation in maize affecting chlorophyll metabolism. We identified a single modifier locus segregating between B73 and Mo17 that was linked to the reporter gene itself, which we call very oil yellow1 (vey1). Based on the variation in OY1 transcript abundance and genome-wide association data, vey1 is predicted to consist of multiple cis-acting regulatory sequence polymorphisms encoded at the wild-type oy1 alleles. The vey1 locus appears to be a common polymorphism in the maize germplasm that alters the expression level of a key gene in chlorophyll biosynthesis. These vey1 alleles have no discernable impact on leaf chlorophyll in the absence of the Oy1-N1989 reporter. Thus, the use of a mutant as a reporter for magnesium chelatase activity resulted in the detection of expression-level polymorphisms not readily visible in the laboratory." @default.
• W2952001657 created "2019-06-27" @default.
• W2952001657 creator A5006192437 @default.
• W2952001657 creator A5011461198 @default.
• W2952001657 creator A5012910801 @default.
• W2952001657 creator A5030771368 @default.
• W2952001657 creator A5035833387 @default.
• W2952001657 creator A5070342025 @default.
• W2952001657 date "2019-02-01" @default.
• W2952001657 modified "2023-10-14" @default.
• W2952001657 title "A<i>Very Oil Yellow1</i>Modifier of the<i>Oil Yellow1-N1989</i>Allele Uncovers a Cryptic Phenotypic Impact of<i>Cis</i>-regulatory Variation in Maize" @default.
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