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- W2952001687 abstract "A straightforward synthesis of 3,4,5-trisubstituted isoxazole derivatives via 1,3-dipolar cycloaddtion/SO2 extrusion of benzoisothiazole-2,2-dioxide-3-ylidenes with nitrile oxides is reported using 4 A molecular sieves as a dehydrochlorinating agent. This tandem ring closing/ring opening synthesis of 3,4,5-trisubstituted isoxazoles is the first of its kind. This methodology would enrich the synthetic chemistry of isoxazoles from easily available starting materials and benefit the discovery of novel isoxazoles with potential biological activities." @default.
- W2952001687 created "2019-06-27" @default.
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- W2952001687 date "2016-06-01" @default.
- W2952001687 modified "2023-09-25" @default.
- W2952001687 title "ChemInform Abstract: Synthesis of 3,4,5-Trisubstituted Isoxazoles via 1,3-Dipolar Cycloaddition/SO2Extrusion of Benzoisothiazole-2,2-dioxide-3-ylidenes with Nitrile Oxides." @default.
- W2952001687 cites W2288010845 @default.
- W2952001687 doi "https://doi.org/10.1002/chin.201628161" @default.
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