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- W2952013225 abstract "The biological significance of genomic features is often context-dependent. We present CruzDB, a fast and intuitive programmatic interface to the UCSC genome browser that facilitates integrative analyses of diverse local and remotely hosted datasets. We showcase the syntax of CruzDB using miRNA-binding sites as examples, and further demonstrate its utility with 3 novel biological discoveries. First, we find that while exons replicate early, introns tend to replicate late, suggesting a complex replication pattern in gene regions. Second, variants associated with cognitive functions map to lincRNA transcripts of relevant function. Third, lamina-associated domains are highly enriched in olfaction-related genes. CruzDB is available at this https URL" @default.
- W2952013225 created "2019-06-27" @default.
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- W2952013225 date "2013-03-14" @default.
- W2952013225 modified "2023-09-27" @default.
- W2952013225 title "CruzDB: software for annotation of genomic intervals with UCSC genome-browser data" @default.
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