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• W2952017566 abstract "Schizophrenia is a chronic debilitating disease. The pathogenesis and treatment may be associated with inflammatory cytokines. There are few studies focusing on the prediction of cytokines in response to antipsychotics.To investigate whether cytokines would predict response to antipsychotics.Cross-sectional and natural observational cohort studies were applied to:(1) compare the baseline levels of serum IL-1β, TNF-α and MCP-1 between schizophrenia (n=64) and healthy controls (n=53); (2) To investigate the impact of baseline cytokines to psychopathology following olanzapine and risperidone monotherapy.(1) Baseline MCP-1 level of patients with schizophrenia was significantly higher than healthy controls (t=2.62, p=0.010), while no significance was found in IL-1β (t=1.43, p=0.154) and TNF-α (t=0.79, p=0.434); (2) Pretreatment level of MCP-1 significantly correlated with PANSS-G reduction following 4 weeks' of risperidone monotherapy (r =-0.658; p<0.001) but not olanzapine monotherapy (r =-0.031; p=0.855); (3) Further stepwise multiple linear regression analysis indicated that higher MCP-1 level prior to treatment was a significant predictor of less PANSS-G reduction in schizophrenia patients following risperidone monotherapy (adjusted R2= 0.409, β = -0.658, p <0.001), but not in the olanzapine group.MCP-1 may play a role in the pathogenesis of schizophrenia. Pretreatment level of MCP-1 may serve as a biomarker indicating response to risperidone treatment.精神分裂症是一种慢性致残性疾病，其发病及 治疗可能与炎性细胞因子有关。目前细胞因子预测抗 精神病药物疗效的研究尚少。.研究细胞因子对抗精神病药物疗效的预测作用。.采用横断面与自然观察随访相结合的方法，（1） 对比精神分裂症患者组（n ＝ 64）基线期和正常对照 组（n＝53）血清IL-1β、TNF-α 和MCP-1 水平；（2） 探索基线期细胞因子水平对奥氮平或利培酮单药治疗 效果的影响。.（1）精神分裂症患者治疗前血清MCP-1 水平 明显高于健康对照组（t=2.62, p=0.010），IL-1β（t=1.43 p=0.154）、TNF-α（t=0.79, p=0.434）未见变化；（2） 精神分裂症患者治疗前MCP-1 水平与利培酮单药治疗 4 周后PANSS 量表一般病理评分的减少量呈显著负相 关（r =-0.658; p ﹤ 0.001），但在奥氮平组中则未发现（r =-0.031; p=0.855）；（3）纳入性别、年龄、受教育年 限和BMI 后等影响因素后，多元线性回归分析发现， 基线血清MCP-1 水平可作为利培酮单药治疗效果的独 立预测因子（校正R2= 0.409, β= -0.658, p ﹤ 0.001）。.MCP-1 可能参与精神分裂症的发生，治疗前血 清MCP-1 水平可能是利培酮疗效预测的生物标记物。." @default.
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• W2952017566 date "2017-10-25" @default.
• W2952017566 modified "2023-10-03" @default.
• W2952017566 title "Pretreatment Serum MCP-1 Level Predicts Response to Risperidone in Schizophrenia." @default.
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• W2952017566 doi "https://doi.org/10.11919/j.issn.1002-0829.217093" @default.
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