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• W2952020133 abstract "ABSTRACT Sequences of circular RNAs (circRNAs) produced from back-splicing of exon(s) completely overlap with sequences from cognate linear RNAs transcribed from the same gene loci with the exception of their back-splicing junction (BSJ) sites. Examination of global circRNA expression from RNA-seq datasets generally relies on the detection of RNA-seq fragments spanning BSJ sites, but a direct comparison of circular and linear RNA expression from the same gene loci in a genome-wide manner has remained challenging. This is because quantification of BSJ fragments differs from that of linear RNA expression that uses normalized RNA-seq fragments mapped to the whole gene bodies. Here, we have developed a computational pipeline for c ircular and linear RNA e xpression a nalysis from ribosomal-RNA depleted RNA-seq (CLEAR, https://github.com/YangLab/CLEAR ). A new quantitation parameter, FPB (fragments p er b illion mapped bases), is applied to evaluate circular and linear RNA expression individually by fragments mapped to circRNA-specific BSJ sites or to linear RNA-specific splicing junction (SJ) sites. Then, circular and linear RNA expression are directly compared by dividing FPB circ by FPB linear to generate a CIRCscore, which indicates the relative circRNA expression using linear RNA expression as the background. Highly-expressed circRNAs with low cognate linear RNA expression background can be identified for further investigation." @default.
• W2952020133 created "2019-06-27" @default.
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• W2952020133 date "2019-06-12" @default.
• W2952020133 modified "2023-09-23" @default.
• W2952020133 title "A CLEAR pipeline for direct comparison of circular and linear RNA expression" @default.
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• W2952020133 doi "https://doi.org/10.1101/668657" @default.
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