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• W2952024360 abstract "Patients with lifestyle-related diseases such as hypertension, diabetes, and hyperlipidemia are at high risk for the pathogenesis of a life-threatening atherosclerotic disease. The elucidation of the mechanism responsible for the pathogenesis can bring about the prevention and the cure of lifestyle-related diseases. We think that abnormal transport of electrolytes in renal tubule is involved in lifestyle-related diseases and renal failure. This review focuses on the regulatory mechanisms of Mg2+ transport pathways in renal tubular cells. Mg2+ filtrated by glomeruli is reabsorbed by transcellular and paracellular pathways in renal epithelial cells. Transient receptor potential melastatin 6 (TRPM6) channel is expressed in the apical membrane and involved in the reabsorption of Mg2+. Cyclosporine A decreased TRPM6 expression and Mg2+ influx, suggesting that the decrease in TRPM6 expression may cause hypomagnesemia. Claudin-16 is expressed in the tight junction (TJ) of the thick ascending limb of Henle and may be involved in the paracellular Mg2+ transport. We found that the phosphorylation of claudin-16 is necessary for its localization on the TJ and claudin-16 is de-phosphorylated in Dahl salt-sensitive (DS) hypertensive rats. In epidemiologic studies, magnesium is the correlate of both systolic and diastolic blood pressure. Dysfunction of claudin-16 may be involved in the salt-sensitive hypertension. Dysfunction of Mg2+ reabsorption in renal tubule may be involved in renal failure and lifestyle-related diseases." @default.
• W2952024360 created "2019-06-27" @default.
• W2952024360 creator A5007615482 @default.
• W2952024360 date "2009-09-01" @default.
• W2952024360 modified "2023-10-02" @default.
• W2952024360 title "Molecular Physiological Study of Electrolyte Transporters in Renal Tubular Epithelial Cells" @default.
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• W2952024360 doi "https://doi.org/10.1248/yakushi.129.1025" @default.
• W2952024360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19721377" @default.
• W2952024360 hasPublicationYear "2009" @default.
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