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- W2952059633 abstract "Abstract The cytoskeleton is a collection of protein assemblies that dynamically impose spatial structure in cells and coordinate processes such as cell division and mechanical regulation. Biopolymer filaments, cross-linking proteins, and enzymatically active motor proteins collectively self-organize into various precise cytoskeletal assemblies critical for specific biological functions. An outstanding question is how the precise spatial organization arises from the component macromolecules. We develop a new system to investigate simple physical mechanisms of self-organization in biological assemblies. Using a minimal set of purified proteins, we create droplets of cross-linked biopolymer filaments. Through the addition of enzymatically active motor proteins we construct composite assemblies, evocative of cellular structures such as spindles, where the inherent anisotropy drives motor self-organization and droplet deformation. These results suggest that simple physical principles underlie the self-organization in complex biological assemblies and inform bio-inspired materials design." @default.
- W2952059633 created "2019-06-27" @default.
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- W2952059633 date "2018-08-29" @default.
- W2952059633 modified "2023-09-26" @default.
- W2952059633 title "Self-organizing motors divide active liquid droplets" @default.
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- W2952059633 doi "https://doi.org/10.1101/403121" @default.
- W2952059633 hasPublicationYear "2018" @default.
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