Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952071811> ?p ?o ?g. }
- W2952071811 endingPage "285" @default.
- W2952071811 startingPage "207" @default.
- W2952071811 abstract "The manzamine alkaloids are unique and viable, lead to the treatment of malaria, as well as other infectious or tropical parasitic diseases, based on their significant activity in animal models. In addition, the relatively wide range of biological activity for the manzamines in vitro raises the question that perhaps these molecules maybe broad-spectrum antiparasitic antibiotics generated by a sponge-associated microbe. The ecological relationship between the microbial communities and the sponge in the case of the manzamines is particularly intriguing because of the structural complexity of these alkaloids. In spite of the necessity of the β-carboline moiety for in vitro antimalarial activity, it has little effect on the antituberculosis activity in vitro, suggesting that different possible mechanisms of action are likely to exist. Few classes of alkaloids are as unique and intriguing as the manzamine class. The biological activity of the manzamines against infectious diseases, cancer, and inflammatory diseases, combined with their unusual structure, strongly suggests that these alkaloids will ultimately yield useful clinical candidates. In addition, the manzamine alkaloids are clearly a key to understanding the sophisticated, but poorly understood, ecological, and phylogenetic relationships between a diverse group of sponges and their associated microbial communities." @default.
- W2952071811 created "2019-06-27" @default.
- W2952071811 creator A5006614163 @default.
- W2952071811 creator A5038919139 @default.
- W2952071811 creator A5067013512 @default.
- W2952071811 creator A5081630594 @default.
- W2952071811 date "2003-01-01" @default.
- W2952071811 modified "2023-10-15" @default.
- W2952071811 title "THE MANZAMINE ALKALOIDS" @default.
- W2952071811 cites W1707296410 @default.
- W2952071811 cites W1965067273 @default.
- W2952071811 cites W1965390227 @default.
- W2952071811 cites W1965964747 @default.
- W2952071811 cites W1967767212 @default.
- W2952071811 cites W1969702695 @default.
- W2952071811 cites W1970329744 @default.
- W2952071811 cites W1971225732 @default.
- W2952071811 cites W1971701551 @default.
- W2952071811 cites W1974060237 @default.
- W2952071811 cites W1974379259 @default.
- W2952071811 cites W1974784973 @default.
- W2952071811 cites W1975538675 @default.
- W2952071811 cites W1976213913 @default.
- W2952071811 cites W1977017361 @default.
- W2952071811 cites W1979293814 @default.
- W2952071811 cites W1980788836 @default.
- W2952071811 cites W1985417437 @default.
- W2952071811 cites W1987254530 @default.
- W2952071811 cites W1992268056 @default.
- W2952071811 cites W1993309588 @default.
- W2952071811 cites W1994712727 @default.
- W2952071811 cites W1997281379 @default.
- W2952071811 cites W1997516945 @default.
- W2952071811 cites W1998995634 @default.
- W2952071811 cites W2000162014 @default.
- W2952071811 cites W2000597330 @default.
- W2952071811 cites W2001589379 @default.
- W2952071811 cites W2003752559 @default.
- W2952071811 cites W2003978468 @default.
- W2952071811 cites W2006224480 @default.
- W2952071811 cites W2006391769 @default.
- W2952071811 cites W2008012163 @default.
- W2952071811 cites W2008765260 @default.
- W2952071811 cites W2009826041 @default.
- W2952071811 cites W2010524382 @default.
- W2952071811 cites W2011548158 @default.
- W2952071811 cites W2013255039 @default.
- W2952071811 cites W2014078770 @default.
- W2952071811 cites W2014322699 @default.
- W2952071811 cites W2014503450 @default.
- W2952071811 cites W2015166407 @default.
- W2952071811 cites W2016483386 @default.
- W2952071811 cites W2019148375 @default.
- W2952071811 cites W2019934214 @default.
- W2952071811 cites W2020211548 @default.
- W2952071811 cites W2021677265 @default.
- W2952071811 cites W2022750336 @default.
- W2952071811 cites W2023205159 @default.
- W2952071811 cites W2024363353 @default.
- W2952071811 cites W2024733113 @default.
- W2952071811 cites W2024893986 @default.
- W2952071811 cites W2028286117 @default.
- W2952071811 cites W2029422082 @default.
- W2952071811 cites W2030161733 @default.
- W2952071811 cites W2030334655 @default.
- W2952071811 cites W2032000617 @default.
- W2952071811 cites W2033557006 @default.
- W2952071811 cites W2034158195 @default.
- W2952071811 cites W2035189222 @default.
- W2952071811 cites W2036125634 @default.
- W2952071811 cites W2037815408 @default.
- W2952071811 cites W2038728493 @default.
- W2952071811 cites W2039914809 @default.
- W2952071811 cites W2039999047 @default.
- W2952071811 cites W2040138814 @default.
- W2952071811 cites W2041880035 @default.
- W2952071811 cites W2042653870 @default.
- W2952071811 cites W2044470761 @default.
- W2952071811 cites W2046184843 @default.
- W2952071811 cites W2048152375 @default.
- W2952071811 cites W2049368915 @default.
- W2952071811 cites W2049589148 @default.
- W2952071811 cites W2051599474 @default.
- W2952071811 cites W2051728525 @default.
- W2952071811 cites W2051751715 @default.
- W2952071811 cites W2052052272 @default.
- W2952071811 cites W2055500327 @default.
- W2952071811 cites W2056055167 @default.
- W2952071811 cites W2059560619 @default.
- W2952071811 cites W2061974499 @default.
- W2952071811 cites W2067441651 @default.
- W2952071811 cites W2067897337 @default.
- W2952071811 cites W2068084635 @default.
- W2952071811 cites W2068475799 @default.
- W2952071811 cites W2068757178 @default.
- W2952071811 cites W2069650445 @default.
- W2952071811 cites W2070446063 @default.
- W2952071811 cites W2077748372 @default.