Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952076908> ?p ?o ?g. }
- W2952076908 abstract "Abstract Cell size, cell growth, and cell cycle events are necessarily intertwined to achieve robust bacterial replication. Yet, a comprehensive and integrated view of these fundamental processes is lacking. Here, we describe an image‐based quantitative screen of the single‐gene knockout collection of Escherichia coli and identify many new genes involved in cell morphogenesis, population growth, nucleoid (bulk chromosome) dynamics, and cell division. Functional analyses, together with high‐dimensional classification, unveil new associations of morphological and cell cycle phenotypes with specific functions and pathways. Additionally, correlation analysis across ~4,000 genetic perturbations shows that growth rate is surprisingly not predictive of cell size. Growth rate was also uncorrelated with the relative timings of nucleoid separation and cell constriction. Rather, our analysis identifies scaling relationships between cell size and nucleoid size and between nucleoid size and the relative timings of nucleoid separation and cell division. These connections suggest that the nucleoid links cell morphogenesis to the cell cycle." @default.
- W2952076908 created "2019-06-27" @default.
- W2952076908 creator A5011205200 @default.
- W2952076908 creator A5015700197 @default.
- W2952076908 creator A5017217582 @default.
- W2952076908 creator A5036388736 @default.
- W2952076908 creator A5041848719 @default.
- W2952076908 creator A5051991967 @default.
- W2952076908 date "2018-06-01" @default.
- W2952076908 modified "2023-10-17" @default.
- W2952076908 title "Genomewide phenotypic analysis of growth, cell morphogenesis, and cell cycle events in <i>Escherichia coli</i>" @default.
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