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• W2952077401 abstract "Proteins and lipids of the plasma membrane underlie constant remodeling via a combination of the secretory- and the endocytic pathway. In the yeast endocytic pathway, cargo is sorted for recycling to the plasma membrane or degradation in vacuoles. Previously we have shown a role for the GARP complex in sphingolipid sorting and homeostasis (Fröhlich et al. 2015). However, the majority of cargo sorted in a GARP dependent process remain largely unknown. Here we use auxin induced degradation of GARP combined with mass spectrometry based vacuolar proteomics and lipidomics to show that recycling of two specific groups of proteins, the amino-phospholipid flippases and cell wall synthesis proteins depends on a functional GARP complex. Our results suggest that mis-sorting of flippases and remodeling of the lipid composition are the first occurring defects in GARP mutants. Our assay can be adapted to systematically map cargo of the entire endocytic pathway." @default.
• W2952077401 created "2019-06-27" @default.
• W2952077401 creator A5071883928 @default.
• W2952077401 creator A5076513550 @default.
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• W2952077401 date "2019-01-29" @default.
• W2952077401 modified "2023-10-18" @default.
• W2952077401 title "A systematic approach to identify recycling endocytic cargo depending on the GARP complex" @default.
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• W2952077401 doi "https://doi.org/10.7554/elife.42837" @default.
• W2952077401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6374077" @default.
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• W2952077401 hasPublicationYear "2019" @default.
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