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- W2952085302 abstract "A group of amides and amines related to 4-amino-N-(1-phenylethyl)benzamide, 1, were prepared in a study on the relationship of structure to anticonvulsant activity in this compound. Acylation and alkylation of the amino group of 1 resulted in almost total loss of anticonvulsant activity. Insertion of a methylene between the 4-amino group and the aromatic ring of 1 produced a slight increase in anticonvulsant potency and a significant increase in toxicity. Hydride reduction of the amide carbonyl in 1 also yielded compounds having a slightly lower ED50 against convulsions induced by electroshock and a much lower TD50 in the rotorod assay. Modification of the 1-phenylethyl group of 1 also decreased anticonvulsant potency." @default.
- W2952085302 created "2019-06-27" @default.
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- W2952085302 date "1987-12-15" @default.
- W2952085302 modified "2023-09-27" @default.
- W2952085302 title "ChemInform Abstract: Synthesis and Anticonvulsant Activity of Analogues of 4-Amino-N-(1-phenylethyl)benzamide." @default.
- W2952085302 cites W2044153425 @default.
- W2952085302 doi "https://doi.org/10.1002/chin.198750154" @default.
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