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• W2952099774 abstract "Abstract Understanding how stochastic molecular fluctuations affect cell behavior requires the quantification of both behavior and protein numbers in the same cells. Here, we combine automated microscopy with in situ hydrogel polymerization to measure single-cell protein expression after tracking swimming behavior. We characterized the distribution of non-genetic phenotypic diversity in Escherichia coli motility, which affects single-cell exploration. By expressing fluorescently tagged chemotaxis proteins (CheR and CheB) at different levels, we quantitatively mapped motile phenotype (tumble bias) to protein numbers using thousands of single-cell measurements. Our results disagreed with established models until we incorporated the role of CheB in receptor deamidation and the slow fluctuations in receptor methylation. Beyond refining models, our central finding is that changes in numbers of CheR and CheB affect the population mean tumble bias and its variance independently. Therefore, it is possible to adjust the degree of phenotypic diversity of a population by adjusting the global level of expression of CheR and CheB while keeping their ratio constant, which, as shown in previous studies, confers functional robustness to the system. Since genetic control of protein expression is heritable, our results suggest that non-genetic diversity in motile behavior is selectable, supporting earlier hypotheses that such diversity confers a selective advantage." @default.
• W2952099774 created "2019-06-27" @default.
• W2952099774 creator A5039355264 @default.
• W2952099774 creator A5049157751 @default.
• W2952099774 creator A5078226296 @default.
• W2952099774 creator A5078236108 @default.
• W2952099774 creator A5088768963 @default.
• W2952099774 date "2016-08-04" @default.
• W2952099774 modified "2023-10-17" @default.
• W2952099774 title "Direct correlation between motile behavior and protein abundance in single cells" @default.
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• W2952099774 doi "https://doi.org/10.1101/067918" @default.
• W2952099774 hasPublicationYear "2016" @default.
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