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- W2952102703 endingPage "838" @default.
- W2952102703 startingPage "838" @default.
- W2952102703 abstract "Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading cause of cancer-related deaths among women worldwide. The main reasons for this poor prognosis are late diagnosis; when the disease is already in an advanced stage, and the frequent development of resistance to current chemotherapeutic regimens. Growing evidence demonstrates that apart from its role in ovarian cancer progression, epithelial-to-mesenchymal transition (EMT) can promote chemotherapy resistance. In this review, we will highlight the contribution of EMT to the distinct steps of ovarian cancer progression. In addition, we will review the different types of ovarian cancer resistance to therapy with particular attention to EMT-mediated mechanisms such as cell fate transitions, enhancement of cancer cell survival, and upregulation of genes related to drug resistance. Preclinical studies of anti-EMT therapies have yielded promising results. However, before anti-EMT therapies can be effectively implemented in clinical trials, more research is needed to elucidate the mechanisms leading to EMT-induced therapy resistance." @default.
- W2952102703 created "2019-06-27" @default.
- W2952102703 creator A5008683883 @default.
- W2952102703 creator A5042838758 @default.
- W2952102703 creator A5061491560 @default.
- W2952102703 creator A5081636497 @default.
- W2952102703 date "2019-06-17" @default.
- W2952102703 modified "2023-10-12" @default.
- W2952102703 title "The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance" @default.
- W2952102703 cites W1499021562 @default.
- W2952102703 cites W1523215342 @default.
- W2952102703 cites W1594020010 @default.
- W2952102703 cites W1760215417 @default.
- W2952102703 cites W1805581579 @default.
- W2952102703 cites W1875101685 @default.
- W2952102703 cites W1947613625 @default.
- W2952102703 cites W1964847767 @default.
- W2952102703 cites W1965568527 @default.
- W2952102703 cites W1966051785 @default.
- W2952102703 cites W1966307963 @default.
- W2952102703 cites W1968109047 @default.
- W2952102703 cites W1979309900 @default.
- W2952102703 cites W1979449717 @default.
- W2952102703 cites W1984413324 @default.
- W2952102703 cites W1984851072 @default.
- W2952102703 cites W1986834354 @default.
- W2952102703 cites W1988509493 @default.
- W2952102703 cites W1989056960 @default.
- W2952102703 cites W1992514491 @default.
- W2952102703 cites W1994563300 @default.
- W2952102703 cites W1996863944 @default.
- W2952102703 cites W1999224816 @default.
- W2952102703 cites W2005852730 @default.
- W2952102703 cites W2009850733 @default.
- W2952102703 cites W2011047198 @default.
- W2952102703 cites W2013107316 @default.
- W2952102703 cites W2013629087 @default.
- W2952102703 cites W2016360721 @default.
- W2952102703 cites W2019156893 @default.
- W2952102703 cites W2019237060 @default.
- W2952102703 cites W2020458598 @default.
- W2952102703 cites W2024297717 @default.
- W2952102703 cites W2031079863 @default.
- W2952102703 cites W2037583144 @default.
- W2952102703 cites W2038843789 @default.
- W2952102703 cites W2039220621 @default.
- W2952102703 cites W2047118480 @default.
- W2952102703 cites W2047172303 @default.
- W2952102703 cites W2052849209 @default.
- W2952102703 cites W2053263835 @default.
- W2952102703 cites W2056569074 @default.
- W2952102703 cites W2058126188 @default.
- W2952102703 cites W2058443035 @default.
- W2952102703 cites W2064255761 @default.
- W2952102703 cites W2069579706 @default.
- W2952102703 cites W2075711878 @default.
- W2952102703 cites W2076036054 @default.
- W2952102703 cites W2079484912 @default.
- W2952102703 cites W2080134369 @default.
- W2952102703 cites W2087025655 @default.
- W2952102703 cites W2087127543 @default.
- W2952102703 cites W2088356680 @default.
- W2952102703 cites W2089818916 @default.
- W2952102703 cites W2094467658 @default.
- W2952102703 cites W2095927032 @default.
- W2952102703 cites W2099384129 @default.
- W2952102703 cites W2104546896 @default.
- W2952102703 cites W2105459360 @default.
- W2952102703 cites W2108619997 @default.
- W2952102703 cites W2109998353 @default.
- W2952102703 cites W2110400064 @default.
- W2952102703 cites W2111564953 @default.
- W2952102703 cites W2112657305 @default.
- W2952102703 cites W2113860186 @default.
- W2952102703 cites W2117111440 @default.
- W2952102703 cites W2123696077 @default.
- W2952102703 cites W2125123416 @default.
- W2952102703 cites W2125460615 @default.
- W2952102703 cites W2126455514 @default.
- W2952102703 cites W2126712477 @default.
- W2952102703 cites W2132927361 @default.
- W2952102703 cites W2136867954 @default.
- W2952102703 cites W2137226085 @default.
- W2952102703 cites W2137750805 @default.
- W2952102703 cites W2144884298 @default.
- W2952102703 cites W2146267383 @default.
- W2952102703 cites W2150111967 @default.
- W2952102703 cites W2150670168 @default.
- W2952102703 cites W2150823776 @default.
- W2952102703 cites W2155567667 @default.
- W2952102703 cites W2157005857 @default.
- W2952102703 cites W2164277862 @default.
- W2952102703 cites W2165201594 @default.
- W2952102703 cites W2170717116 @default.
- W2952102703 cites W2187941593 @default.
- W2952102703 cites W2209686463 @default.
- W2952102703 cites W2223385340 @default.
- W2952102703 cites W2256481109 @default.