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- W2952151738 abstract "An opinion on the opportunity and the role of synthetic organic chemistry in 21st century's life science is described. Particularly emphasized is the importance of the creation of designed molecules. Designed molecules are the tools that can regulate biofunctions by stimulating or inhibiting target proteins such as membrane receptors through specific binding. The effective utilization of designed molecules will contribute to the elucidation of complex biosignal transduction mechanisms at the molecular level. The subject includes : (1) Introduction; (2) Definition of designed molecules; (3) Receptors and signal transduction (3.1) Membrane receptors and ion channels; (3.2) Protein kinases and H-inhibitors; (3.3) Immune response and receptor signaling; (3.4) Cell cycle and biosignals; (3.5) Lipids as signaling molecules; (3.6) From molecular level to vital systems; (4) Prostaglandins (PGs) and biofunctions (4.1) PG receptors and functions; (4.2) Design and synthesis of specific molecular probes for PG receptor signaling and the use in biology; (5) Perspectives in the 21st century. At present, the PG bioscience faces to a new phase based on molecular level investigation of the signaling functions of PG receptors. In this context, current topics in this field are overviewed in subject 4. The results described in subject 4.2. have been developed by authors in collaboration with biochemists." @default.
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- W2952151738 date "1997-01-01" @default.
- W2952151738 modified "2023-10-02" @default.
- W2952151738 title "Challenge of Organic Synthesis-toward the 21st Century. Construction of the Software to Control Biofunctions with Designed Molecules." @default.
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- W2952151738 doi "https://doi.org/10.5059/yukigoseikyokaishi.55.365" @default.
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