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- W2952152023 abstract "Abstract Mammalian mitochondria have small genomes encoding very limited numbers of proteins. Over one thousand proteins and noncoding RNAs encoded by nuclear genome have to be imported from the cytosol into the mitochondria. Here we report the identification of hundreds of circular RNAs (mecciRNAs) encoded by mitochondrial genome. We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins. Known components of mitochondrial protein and RNA importation such as TOM40 and PNPASE interact with mecciRNAs and regulate protein entry. Expression of mecciRNAs is regulated, and these transcripts are critical for mitochondria in adapting to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation. mecciRNAs and their associated physiological roles add categories and functions to eukaryotic circular RNAs, and shed novel lights on communication between mitochondria and nucleus." @default.
- W2952152023 created "2019-06-27" @default.
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- W2952152023 date "2019-06-12" @default.
- W2952152023 modified "2023-09-23" @default.
- W2952152023 title "The identification of mecciRNAs and their roles in mitochondrial entry of proteins" @default.
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- W2952152023 doi "https://doi.org/10.1101/668665" @default.
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