Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952171610> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2952171610 abstract "Although DNA damage is widely viewed as a critical target for the induction of cell killing by ionizing radiation, the exact nature of DNA damage responsible for these effects is unknown. To address this issue, the probability of forming lethal damage by single proton tracks, derived from published survival data for Chinese hamster V79 cells irradiated by protons with energies from 0.57 to 5.01 MeV, has been compared to estimated yields of clustered DNA lesions and repair outcomes calculated with Monte Carlo models. The reported studies provide new information about the potential relationship between the induction and repair of clustered DNA damage and trends in the expected number of lethal events for protons with increasing linear energy transfer (LET). A good correlation was found between the number of lethal events in V79 cells and the induction of double-strand breaks (DSBs) consisting of 3 or more elementary DNA lesions. For the yields of other types of DNA damage, as well as point mutations formed through the misrepair of base damage and single-strand breaks, observed trends with increasing LET are not consistent with trends in the yields of lethal events. This observation suggests that the relative biological effectiveness (RBE) of protons of varying quality may be more closely related to the induction of complex DSBs rather than other forms of damage." @default.
- W2952171610 created "2019-06-27" @default.
- W2952171610 creator A5029902179 @default.
- W2952171610 creator A5065627326 @default.
- W2952171610 date "2005-12-05" @default.
- W2952171610 modified "2023-09-27" @default.
- W2952171610 title "On the biophysical interpretation of lethal DNA lesions induced by ionizing radiation" @default.
- W2952171610 cites W1738098045 @default.
- W2952171610 cites W2019963243 @default.
- W2952171610 cites W2068449224 @default.
- W2952171610 cites W2072845369 @default.
- W2952171610 cites W2078207423 @default.
- W2952171610 cites W2113777563 @default.
- W2952171610 cites W2128066858 @default.
- W2952171610 cites W2155976688 @default.
- W2952171610 cites W2156654372 @default.
- W2952171610 cites W2175899622 @default.
- W2952171610 hasPublicationYear "2005" @default.
- W2952171610 type Work @default.
- W2952171610 sameAs 2952171610 @default.
- W2952171610 citedByCount "2" @default.
- W2952171610 crossrefType "posted-content" @default.
- W2952171610 hasAuthorship W2952171610A5029902179 @default.
- W2952171610 hasAuthorship W2952171610A5065627326 @default.
- W2952171610 hasConcept C111337013 @default.
- W2952171610 hasConcept C11928243 @default.
- W2952171610 hasConcept C121332964 @default.
- W2952171610 hasConcept C12554922 @default.
- W2952171610 hasConcept C134935766 @default.
- W2952171610 hasConcept C143425029 @default.
- W2952171610 hasConcept C151337348 @default.
- W2952171610 hasConcept C153428861 @default.
- W2952171610 hasConcept C18231593 @default.
- W2952171610 hasConcept C185544564 @default.
- W2952171610 hasConcept C185592680 @default.
- W2952171610 hasConcept C2777755551 @default.
- W2952171610 hasConcept C2992406208 @default.
- W2952171610 hasConcept C54355233 @default.
- W2952171610 hasConcept C552990157 @default.
- W2952171610 hasConcept C86611320 @default.
- W2952171610 hasConcept C86803240 @default.
- W2952171610 hasConceptScore W2952171610C111337013 @default.
- W2952171610 hasConceptScore W2952171610C11928243 @default.
- W2952171610 hasConceptScore W2952171610C121332964 @default.
- W2952171610 hasConceptScore W2952171610C12554922 @default.
- W2952171610 hasConceptScore W2952171610C134935766 @default.
- W2952171610 hasConceptScore W2952171610C143425029 @default.
- W2952171610 hasConceptScore W2952171610C151337348 @default.
- W2952171610 hasConceptScore W2952171610C153428861 @default.
- W2952171610 hasConceptScore W2952171610C18231593 @default.
- W2952171610 hasConceptScore W2952171610C185544564 @default.
- W2952171610 hasConceptScore W2952171610C185592680 @default.
- W2952171610 hasConceptScore W2952171610C2777755551 @default.
- W2952171610 hasConceptScore W2952171610C2992406208 @default.
- W2952171610 hasConceptScore W2952171610C54355233 @default.
- W2952171610 hasConceptScore W2952171610C552990157 @default.
- W2952171610 hasConceptScore W2952171610C86611320 @default.
- W2952171610 hasConceptScore W2952171610C86803240 @default.
- W2952171610 hasLocation W29521716101 @default.
- W2952171610 hasOpenAccess W2952171610 @default.
- W2952171610 hasPrimaryLocation W29521716101 @default.
- W2952171610 hasRelatedWork W1976195362 @default.
- W2952171610 hasRelatedWork W2030231398 @default.
- W2952171610 hasRelatedWork W2031391207 @default.
- W2952171610 hasRelatedWork W2032420732 @default.
- W2952171610 hasRelatedWork W2051202148 @default.
- W2952171610 hasRelatedWork W2081443886 @default.
- W2952171610 hasRelatedWork W2097531570 @default.
- W2952171610 hasRelatedWork W2106888439 @default.
- W2952171610 hasRelatedWork W2154242458 @default.
- W2952171610 hasRelatedWork W2157060098 @default.
- W2952171610 hasRelatedWork W2415693049 @default.
- W2952171610 hasRelatedWork W2511265374 @default.
- W2952171610 hasRelatedWork W2568327975 @default.
- W2952171610 hasRelatedWork W2898533126 @default.
- W2952171610 hasRelatedWork W2995138920 @default.
- W2952171610 hasRelatedWork W3167646383 @default.
- W2952171610 hasRelatedWork W3200193428 @default.
- W2952171610 hasRelatedWork W355824321 @default.
- W2952171610 hasRelatedWork W790153186 @default.
- W2952171610 hasRelatedWork W2984714577 @default.
- W2952171610 isParatext "false" @default.
- W2952171610 isRetracted "false" @default.
- W2952171610 magId "2952171610" @default.
- W2952171610 workType "article" @default.