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- W2952182261 abstract "BackgroundThe Charlson Comorbidity Index (CCI) is frequently used to control for confounding by comorbidities in observational studies, but its performance as such has not been studied. We evaluated the performance of CCI and an alternative summary method, logistic principal component analysis (LPCA), to adjust for comorbidities, using as an example the association between insurance and mortality.Materials and methodsUsing all admissions in the National Trauma Data Bank 2010-2015, we extracted mortality, payment method, and 36 International Classification of Disease, Ninth Revision–derived comorbidities. We estimated odds ratios (ORs) for the association between uninsured status and mortality before and after adjusting for CCI, LPCA, and separate covariates. We also calculated standardized mean differences (SMDs) of comorbidity variables before and after weighting the sample using inverse probability of treatment weights for CCI, LPCA, and separate covariates.ResultsIn 4,936,880 admissions, most (68.3%) had at least one comorbidity. Considerable imbalance was observed in the unweighted sample (mean SMD = 0.086, OR = 1.17), which was almost entirely eliminated by inverse probability of treatment weights on separate covariates (mean SMD = 0.012, OR = 1.36). The CCI performed similarly to the unweighted sample (mean SMD = 0.080, OR = 1.25), whereas two LPCA axes were better able to control for confounding (mean SMD = 0.04, OR = 1.31). Using covariate adjustment, the CCI accounted for 56.1% of observed confounding, whereas two LPCA axes accounted for 91.3%.ConclusionsThe use of the CCI to adjust for confounding may result in residual confounding, and alternative strategies should be considered. LPCA may be a viable alternative to adjusting for each comorbidity when samples are small or positivity assumptions are violated." @default.
- W2952182261 created "2019-06-27" @default.
- W2952182261 creator A5030609254 @default.
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- W2952182261 date "2019-04-01" @default.
- W2952182261 modified "2023-09-26" @default.
- W2952182261 title "The Charlson Index Is Insufficient to Control for Comorbidities in a National Trauma Registry" @default.
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- W2952182261 doi "https://doi.org/10.1016/j.jss.2018.07.072" @default.
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