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- W2952202434 abstract "A series of A-ring unsaturated 3-nitrosteroids has been prepared and assayed in vitro as inhibitors of steroid 5α-reductase. One of these compounds, 3-nitro-5α-androst-3-ene-17β-diisopropylcarboxamide (4), inhibits the human enzyme with a Ki of 50 nM and exhibits competitive inhibition versus testosterone. Potent oral activity of 4 was demonstrated in cynomolgus monkeys." @default.
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- W2952202434 date "1991-01-01" @default.
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- W2952202434 title "Inhibition of steroid 5α-reductase by 3-nitrosteroids: synthesis, mechanism of inhibition, and in vivo activity." @default.
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- W2952202434 doi "https://doi.org/10.1016/s0960-894x(01)81084-2" @default.
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