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• W2952202508 abstract "Abstract Rule‐based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from rule‐based methods often does not match histological data in other areas of the heart such as the right ventricle, having a negative impact in cardiac simulations beyond the left ventricle. In this work, we present a rule‐based method where fiber orientation is separately modeled in each ventricle following observations from histology. This allows to create detailed fiber orientation in specific regions such as the endocardium of the right ventricle, the interventricular septum, and the outflow tracts. We also carried out electrophysiological simulations involving these structures and with different fiber configurations. In particular, we built a modeling pipeline for creating patient‐specific volumetric meshes of biventricular geometries, including the outflow tracts, and subsequently simulate the electrical wavefront propagation in outflow tract ventricular arrhythmias with different origins for the ectopic focus. The resulting simulations with the proposed rule‐based method showed a very good agreement with clinical parameters such as the 10 ms isochrone ratio in a cohort of nine patients suffering from this type of arrhythmia. The developed modeling pipeline confirms its potential for an in silico identification of the site of origin in outflow tract ventricular arrhythmias before clinical intervention." @default.
• W2952202508 created "2019-06-27" @default.
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• W2952202508 date "2019-02-19" @default.
• W2952202508 modified "2023-10-18" @default.
• W2952202508 title "A rule‐based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts" @default.
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• W2952202508 doi "https://doi.org/10.1002/cnm.3185" @default.
• W2952202508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30721579" @default.
• W2952202508 hasPublicationYear "2019" @default.
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