Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952202842> ?p ?o ?g. }
- W2952202842 abstract "Abstract Plasma cells in human bone marrow (BM) are thought to be responsible for sustaining lifelong immunity, but its underlying basis is controversial. Here we use high-throughput sequence analysis of the same individual across 6.5 years to show that the BM plasma cell immunoglobulin heavy chain repertoire is remarkably stable over time. We find a nearly static bias in individual and combinatorial gene usage across time. Analysis of a second donor corroborates these observations. We also report the persistence of numerous BM plasma cell clonotypes (∼2%) identifiable at all points assayed across 6.5 years, supporting a model of serological memory based upon intrinsic longevity of human plasma cells. Donors were adolescents who completely recovered from neuroblastoma prior to the start of this study. Our work will facilitate differentiation between healthy and diseased antibody repertoires, by serving as a point of comparison with future deep-sequencing studies involving immune intervention." @default.
- W2952202842 created "2019-06-27" @default.
- W2952202842 creator A5043980495 @default.
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- W2952202842 date "2016-12-21" @default.
- W2952202842 modified "2023-09-27" @default.
- W2952202842 title "Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire" @default.
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- W2952202842 doi "https://doi.org/10.1038/ncomms13838" @default.
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- W2952202842 hasPublicationYear "2016" @default.
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