Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952203707> ?p ?o ?g. }
- W2952203707 endingPage "600" @default.
- W2952203707 startingPage "590" @default.
- W2952203707 abstract "Numerous studies have identified potential risk factors and biomarkers for autism spectrum disorder. We aimed to study the strength and validity of the suggested environmental risk factors or biomarkers of autism spectrum disorder.We did an umbrella review and systematically appraised the relevant meta-analyses of observational studies. We searched PubMed, Embase, and the Cochrane Database of Systematic Reviews for papers published between database inception and Oct 17, 2018, and screened the reference list of relevant articles. We obtained the summary effect, 95% CI, heterogeneity, and 95% prediction intervals. We examined small study effects and excess significance. We did analyses under credibility ceilings. This review is registered with PROSPERO, number CRD42018091704.46 eligible articles yielded data on 67 environmental risk factors (544 212 cases, 81 708 787 individuals) and 52 biomarkers (15 614 cases, 15 433 controls). Evidence of association was convincing for maternal age of 35 years or over (relative risk [RR] 1·31, 95% CI 1·18-1·45), maternal chronic hypertension (odds ratio [OR] 1·48, 1·29-1·70), maternal gestational hypertension (OR 1·37, 1·21-1·54), maternal overweight before or during pregnancy (RR 1·28, 1·19-1·36), pre-eclampsia (RR 1·32, 1·20-1·45), prepregnancy maternal antidepressant use (RR 1·48, 1·29-1·71), and maternal selective serotonin reuptake inhibitor (SSRI) use during pregnancy (OR 1·84, 1·60-2·11). Only two associations, maternal overweight before or during pregnancy and SSRI use during pregnancy, retained their high level of evidence under subset sensitivity analyses. Evidence from biomarkers was scarce, being supported by p values close to the significance threshold and too few cases.Convincing evidence suggests that maternal factors, such as age and features of metabolic syndrome, are associated with risk of autism spectrum disorder. Although SSRI use during pregnancy was also associated with such risk when exposed and non-exposed groups were compared, this association could be affected by other confounding factors, considering that prepregnancy maternal antidepressant use was also convincingly associated with higher risk of autism spectrum disorder. Findings from previous studies suggest that one possible confounding factor is underlying maternal psychiatric disorders.None." @default.
- W2952203707 created "2019-06-27" @default.
- W2952203707 creator A5005008571 @default.
- W2952203707 creator A5006333624 @default.
- W2952203707 creator A5013898829 @default.
- W2952203707 creator A5015077266 @default.
- W2952203707 creator A5017280751 @default.
- W2952203707 creator A5034103150 @default.
- W2952203707 creator A5047608893 @default.
- W2952203707 creator A5050172453 @default.
- W2952203707 creator A5051876759 @default.
- W2952203707 creator A5057701634 @default.
- W2952203707 creator A5059447980 @default.
- W2952203707 creator A5059513329 @default.
- W2952203707 creator A5060026865 @default.
- W2952203707 creator A5063687983 @default.
- W2952203707 creator A5073286552 @default.
- W2952203707 creator A5083734796 @default.
- W2952203707 date "2019-07-01" @default.
- W2952203707 modified "2023-10-18" @default.
- W2952203707 title "Environmental risk factors and biomarkers for autism spectrum disorder: an umbrella review of the evidence" @default.
- W2952203707 cites W15569989 @default.
- W2952203707 cites W1808780225 @default.
- W2952203707 cites W1879435919 @default.
- W2952203707 cites W1963924490 @default.
- W2952203707 cites W1966773673 @default.
- W2952203707 cites W1969682776 @default.
- W2952203707 cites W1978097115 @default.
- W2952203707 cites W2001871336 @default.
- W2952203707 cites W2002654991 @default.
- W2952203707 cites W2005317772 @default.
- W2952203707 cites W2010361292 @default.
- W2952203707 cites W2025651303 @default.
- W2952203707 cites W2025926911 @default.
- W2952203707 cites W2035339084 @default.
- W2952203707 cites W2045256384 @default.
- W2952203707 cites W2046989317 @default.
- W2952203707 cites W2052931028 @default.
- W2952203707 cites W2055596672 @default.
- W2952203707 cites W2073677120 @default.
- W2952203707 cites W2078323753 @default.
- W2952203707 cites W2108116635 @default.
- W2952203707 cites W2114299672 @default.
- W2952203707 cites W2117323553 @default.
- W2952203707 cites W2120181870 @default.
- W2952203707 cites W2128246772 @default.
- W2952203707 cites W2131104106 @default.
- W2952203707 cites W2133413753 @default.
- W2952203707 cites W2134787854 @default.
- W2952203707 cites W2135486087 @default.
- W2952203707 cites W2139168999 @default.
- W2952203707 cites W2142647774 @default.
- W2952203707 cites W2142654785 @default.
- W2952203707 cites W2142836240 @default.
- W2952203707 cites W2144981148 @default.
- W2952203707 cites W2150215887 @default.
- W2952203707 cites W2157823046 @default.
- W2952203707 cites W2158197814 @default.
- W2952203707 cites W2163408766 @default.
- W2952203707 cites W2164646777 @default.
- W2952203707 cites W2171607710 @default.
- W2952203707 cites W2183980047 @default.
- W2952203707 cites W2201776847 @default.
- W2952203707 cites W2258842160 @default.
- W2952203707 cites W2290092892 @default.
- W2952203707 cites W2315123323 @default.
- W2952203707 cites W2346577083 @default.
- W2952203707 cites W2346907797 @default.
- W2952203707 cites W2400490165 @default.
- W2952203707 cites W2417157474 @default.
- W2952203707 cites W2434625472 @default.
- W2952203707 cites W2461432150 @default.
- W2952203707 cites W2470416911 @default.
- W2952203707 cites W2479333835 @default.
- W2952203707 cites W2512752893 @default.
- W2952203707 cites W2514329779 @default.
- W2952203707 cites W2517571389 @default.
- W2952203707 cites W2522738868 @default.
- W2952203707 cites W2526143926 @default.
- W2952203707 cites W2545020880 @default.
- W2952203707 cites W2554063892 @default.
- W2952203707 cites W2587924207 @default.
- W2952203707 cites W2587965857 @default.
- W2952203707 cites W2589793208 @default.
- W2952203707 cites W2592578600 @default.
- W2952203707 cites W2596453284 @default.
- W2952203707 cites W2604214406 @default.
- W2952203707 cites W2611128431 @default.
- W2952203707 cites W2638748052 @default.
- W2952203707 cites W2640750616 @default.
- W2952203707 cites W2734994920 @default.
- W2952203707 cites W2737663350 @default.
- W2952203707 cites W2752707502 @default.
- W2952203707 cites W2761279675 @default.
- W2952203707 cites W2766717141 @default.
- W2952203707 cites W2769609168 @default.
- W2952203707 cites W2770549430 @default.
- W2952203707 cites W2773747068 @default.