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- W2952203741 endingPage "249" @default.
- W2952203741 startingPage "238" @default.
- W2952203741 abstract "Chromosomal architecture is known to influence gene expression, yet its role in controlling cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem cells (PSCs) by the transcription factors (TFs) OCT4, SOX2, KLF4 and MYC offers an opportunity to address this question but is severely limited by the low proportion of responding cells. We have recently developed a highly efficient reprogramming protocol that synchronously converts somatic into pluripotent stem cells. Here, we used this system to integrate time-resolved changes in genome topology with gene expression, TF binding and chromatin-state dynamics. The results showed that TFs drive topological genome reorganization at multiple architectural levels, often before changes in gene expression. Removal of locus-specific topological barriers can explain why pluripotency genes are activated sequentially, instead of simultaneously, during reprogramming. Together, our results implicate genome topology as an instructive force for implementing transcriptional programs and cell fate in mammals." @default.
- W2952203741 created "2019-06-27" @default.
- W2952203741 creator A5004164389 @default.
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- W2952203741 creator A5082758634 @default.
- W2952203741 creator A5082958010 @default.
- W2952203741 creator A5084274556 @default.
- W2952203741 date "2018-01-15" @default.
- W2952203741 modified "2023-10-18" @default.
- W2952203741 title "Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming" @default.
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