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- W2952204315 abstract "The amalgamation of two of combinatorial chemistry's most attractive concepts--natural product libraries and multicomponent reactions (MCRs)--should provide a powerful tactic for generating libraries of bioactive compounds. Yet, despite many recent advances in this area, only a few MCRs can deliver functionalized products whose structures closely resemble that of complex polycyclic natural products. A large proportion of recently developed MCRs are based on [4+2] or [3+2] cycloadditions, and isocyanide-based processes. Because of substrate limitations, however, they are not always ideally suitable for applications in diversity-oriented synthesis of natural product-like compounds. A promising area awaiting further development is the use of transition metal-catalyzed cascade reactions." @default.
- W2952204315 created "2019-06-27" @default.
- W2952204315 creator A5020788587 @default.
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- W2952204315 date "2005-06-01" @default.
- W2952204315 modified "2023-10-18" @default.
- W2952204315 title "Wanted: new multicomponent reactions for generating libraries of polycyclic natural products" @default.
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- W2952204315 doi "https://doi.org/10.1016/j.cbpa.2005.04.003" @default.
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