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- W2952208718 abstract "Although telomere length (TL) shortens with age in most tissues, an age-related increase in length has been described in sperm through a mechanism that is not yet fully understood. Changes in TL with age in the same individual have not been explored. This longitudinal study examines TL dynamics in somatic tissue and gametes during an entire lifespan in an outbred mouse population (from 8 to up to 114 weeks of age). Our findings indicate a reduced life expectancy in males compared to females (84.75 ± 9.23 vs. 113.16 ± 0.20 weeks) and significant variability in TL dynamics between individuals. While with aging, a clear reduction in TL was produced in somatic cells and oocytes, telomeres in sperm cells significantly lengthened. Finally, we found evidence indicating that telomere elongation in sperm during aging may be dependent on different mechanisms, such as the survival of spermatogonia with longer telomeres and the alternative lengthening of telomeres mechanism in meiotic and postmeiotic spermatogenic cells." @default.
- W2952208718 created "2019-06-27" @default.
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- W2952208718 date "2019-06-17" @default.
- W2952208718 modified "2023-10-18" @default.
- W2952208718 title "Longitudinal analysis of somatic and germ‐cell telomere dynamics in outbred mice" @default.
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- W2952208718 doi "https://doi.org/10.1002/mrd.23218" @default.
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