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• W2952209984 abstract "PEGylated liposomes (approximately 100 nm in diameter) lose their long-circulating characteristic upon repeated injection at certain intervals in the same animal (referred to as the accelerated blood clearance (ABC) phenomenon), as described by our group and by researchers in the Netherlands. Recently, it was demonstrated by our group that anti-PEG IgM, induced by the first dose of PEGylated liposomes, is responsible for the ABC phenomenon. The IgM produced in this manner then selectively bound to the surface of subsequently injected PEGylated liposomes, leading to substantial complement activation. It is generally believed that nanocarriers coated with a polymer, such as PEG, have no immunogenicity. However, unexpected immune responses occurred even in response to polymer-coated liposomes. This immunogenicity to PEGylated liposomes presents a serious concern in the development and clinical use of liposomal formulations. In this review, we demonstrate our recent observations regarding with the ABC phenomenon against liposomes." @default.
• W2952209984 created "2019-06-27" @default.
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• W2952209984 date "2008-02-01" @default.
• W2952209984 modified "2023-10-14" @default.
• W2952209984 title "Accelerated Blood Clearance (ABC) Phenomenon Induced by Administration of PEGylated Liposome" @default.
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• W2952209984 doi "https://doi.org/10.1248/yakushi.128.233" @default.
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