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- W2952236365 abstract "Peptidoaminobenzophenones (1), terminal N-substituted peptidoaminobenzophenones (14), and acylglycylaminobenzophenones (16) were prepared as a novel series of ring-opened derivatives of 1,4-benzodiazepine. Z-Gly- and Z-Ala-N-methylaminobenzophenones (4) were treated with HBr-HOAc to give Gly- and Ala-N-methylaminobenzophenone hydrobromides (8). Reaction of 8 with chloroacetyl chloride in dimethylformamide (DMF) or hexamethylphosphoramide (HMPA) gave chloracetamide (13), which was allowed to react with various amines to afford a number of terminal N-substituted derivatives (14). Reaction of 8 with various acyl halides in HMPA or DMF gave a number of acylglycyl-N-methylaminobenzophenones (16). Peptidoaminobenzophenones (1) were also prepared by several convenient methods. Many of these compounds exhibited high CNS activity in animals when given orally. In antianxiety activity the potency of some compounds is equal to or higher than that of diazepam." @default.
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- W2952236365 date "1981-06-09" @default.
- W2952236365 modified "2023-09-23" @default.
- W2952236365 title "ChemInform Abstract: NOVEL PEPTIDOAMINOBENZOPHENONES, TERMINAL N-SUBSTITUTED PEPTIDOAMINOBENZOPHENONES, AND N-(ACYLGLYCYL)AMINOBENZOPHENONES AS OPEN-RING DERIVATIVES OF BENZODIAZEPINES" @default.
- W2952236365 cites W2004469144 @default.
- W2952236365 doi "https://doi.org/10.1002/chin.198123204" @default.
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