FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952246543> ?p ?o ?g. }

• W2952246543 endingPage "4262" @default.
• W2952246543 startingPage "4251" @default.
• W2952246543 abstract "Key points Experimental maternal allergic asthma in sheep provides an experimental model in which to test impacts on progeny. Fetuses from allergic asthmatic ewes had fewer surfactant‐producing cells in lungs. A greater proportion of lymphocytes from thymus were CD44 positive in fetuses from allergic asthmatic ewes than in controls. These changes to fetal development might contribute to poor neonatal lung function and increased risk of allergy seen in offspring of pregnancies complicated by asthma. Abstract Asthma is prevalent in pregnancy and increases the risk of disease in offspring, including neonatal respiratory distress and childhood asthma and allergy, but the mechanisms are not understood. We hypothesized that fetal lung structure and immune phenotype in late gestation fetal sheep would be impaired in our sheep model of maternal allergic asthma during pregnancy. Singleton‐bearing ewes were either sensitized before pregnancy to house dust mite (HDM, allergic, n = 7) or were non‐allergic (control, n = 5). The ewes were subsequently subjected to repeated airway challenges with HDM (allergic group) or saline (control group) throughout gestation. Tissues were collected at 140 ± 1 days gestational age (term, ∼147 days). The density of type II alveolar epithelial cells (surfactant protein C‐immunostained) in the lungs was 30% lower in fetuses from allergic ewes than in controls ( P < 0.001), but tissue‐to‐air space ratio and numbers of leucocytes and macrophages were not different between groups. The proportion of CD44 + lymphocytes in the fetal thymus was 3.5‐fold higher in fetuses from allergic ewes than in control ewes ( P = 0.043). Fewer surfactant‐producing type II alveolar epithelial cells may contribute to the increased risk of neonatal respiratory distress in infants of asthmatic mothers, suggesting that interventions to promote lung maturation could improve their neonatal outcomes. If the elevated lymphocyte expression of CD44 persists postnatally, this would confer greater susceptibility to allergic diseases in progeny of asthmatic mothers, consistent with observations in humans. Further experiments are needed to evaluate postnatal phenotypes of progeny and investigate potential interventions." @default.
• W2952246543 created "2019-06-27" @default.
• W2952246543 creator A5006171507 @default.
• W2952246543 creator A5023516469 @default.
• W2952246543 creator A5023962612 @default.
• W2952246543 creator A5024137694 @default.
• W2952246543 creator A5029587218 @default.
• W2952246543 creator A5047956479 @default.
• W2952246543 creator A5062502932 @default.
• W2952246543 creator A5065477099 @default.
• W2952246543 creator A5068075766 @default.
• W2952246543 creator A5080823114 @default.
• W2952246543 creator A5082190328 @default.
• W2952246543 creator A5090518842 @default.
• W2952246543 date "2019-07-03" @default.
• W2952246543 modified "2023-10-11" @default.
• W2952246543 title "Maternal allergic asthma during pregnancy alters fetal lung and immune development in sheep: potential mechanisms for programming asthma and allergy" @default.
• W2952246543 cites W1604037801 @default.
• W2952246543 cites W1756972732 @default.
• W2952246543 cites W1809225494 @default.
• W2952246543 cites W1883301416 @default.
• W2952246543 cites W1963836431 @default.
• W2952246543 cites W1979413706 @default.
• W2952246543 cites W1996979403 @default.
• W2952246543 cites W2017714767 @default.
• W2952246543 cites W2026927047 @default.
• W2952246543 cites W2031494108 @default.
• W2952246543 cites W2033981227 @default.
• W2952246543 cites W2035451762 @default.
• W2952246543 cites W2047316934 @default.
• W2952246543 cites W2061820904 @default.
• W2952246543 cites W2062264071 @default.
• W2952246543 cites W2066679622 @default.
• W2952246543 cites W2067363538 @default.
• W2952246543 cites W2074607864 @default.
• W2952246543 cites W2077941158 @default.
• W2952246543 cites W2084475527 @default.
• W2952246543 cites W2087568937 @default.
• W2952246543 cites W2088444039 @default.
• W2952246543 cites W2091581194 @default.
• W2952246543 cites W2091667585 @default.
• W2952246543 cites W2099630400 @default.
• W2952246543 cites W2108499873 @default.
• W2952246543 cites W2111549179 @default.
• W2952246543 cites W2113568840 @default.
• W2952246543 cites W2114895218 @default.
• W2952246543 cites W2127172916 @default.
• W2952246543 cites W2132320643 @default.
• W2952246543 cites W2133864761 @default.
• W2952246543 cites W2138913184 @default.
• W2952246543 cites W2144436163 @default.
• W2952246543 cites W2152722283 @default.
• W2952246543 cites W2158809411 @default.
• W2952246543 cites W2160624031 @default.
• W2952246543 cites W2271392353 @default.
• W2952246543 cites W2276217657 @default.
• W2952246543 cites W2281194517 @default.
• W2952246543 cites W2339626664 @default.
• W2952246543 cites W2341834489 @default.
• W2952246543 cites W2523070972 @default.
• W2952246543 cites W2599345944 @default.
• W2952246543 cites W2790688465 @default.
• W2952246543 cites W2896962462 @default.
• W2952246543 cites W4256255843 @default.
• W2952246543 doi "https://doi.org/10.1113/jp277952" @default.
• W2952246543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31192454" @default.
• W2952246543 hasPublicationYear "2019" @default.
• W2952246543 type Work @default.
• W2952246543 sameAs 2952246543 @default.
• W2952246543 citedByCount "10" @default.
• W2952246543 countsByYear W29522465432019 @default.
• W2952246543 countsByYear W29522465432020 @default.
• W2952246543 countsByYear W29522465432021 @default.
• W2952246543 countsByYear W29522465432023 @default.
• W2952246543 crossrefType "journal-article" @default.
• W2952246543 hasAuthorship W2952246543A5006171507 @default.
• W2952246543 hasAuthorship W2952246543A5023516469 @default.
• W2952246543 hasAuthorship W2952246543A5023962612 @default.
• W2952246543 hasAuthorship W2952246543A5024137694 @default.
• W2952246543 hasAuthorship W2952246543A5029587218 @default.
• W2952246543 hasAuthorship W2952246543A5047956479 @default.
• W2952246543 hasAuthorship W2952246543A5062502932 @default.
• W2952246543 hasAuthorship W2952246543A5065477099 @default.
• W2952246543 hasAuthorship W2952246543A5068075766 @default.
• W2952246543 hasAuthorship W2952246543A5080823114 @default.
• W2952246543 hasAuthorship W2952246543A5082190328 @default.
• W2952246543 hasAuthorship W2952246543A5090518842 @default.
• W2952246543 hasBestOaLocation W29522465431 @default.
• W2952246543 hasConcept C112672928 @default.
• W2952246543 hasConcept C126322002 @default.
• W2952246543 hasConcept C172680121 @default.
• W2952246543 hasConcept C203014093 @default.
• W2952246543 hasConcept C207480886 @default.
• W2952246543 hasConcept C2776042228 @default.
• W2952246543 hasConcept C2777714996 @default.
• W2952246543 hasConcept C2778166374 @default.
• W2952246543 hasConcept C2779234561 @default.
• W2952246543 hasConcept C2780510475 @default.

• next