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- W2952248794 abstract "SUMMARY Cellular DNA damage response (DDR) involves dramatic transcriptional alterations, the mechanisms of which remain ill-defined. Given the centrality of RNA polymerase II (Pol II) promoter-proximal pause release in transcriptional control, we evaluated its importance in DDR. Here we show that following genotoxic stress, the RNA-binding motif protein 7 (RBM7) stimulates Pol II elongation and promotes cell viability by activating the positive transcription elongation factor b (P-TEFb). This is mediated by genotoxic stress-enhanced binding of RBM7 to 7SK snRNA (7SK), the scaffold of the 7SK small nuclear ribonucleoprotein (7SK snRNP) which inhibits P-TEFb. In turn, P-TEFb relocates from 7SK snRNP to chromatin to induce transcription of short units including key DDR genes and multiple classes of non-coding RNAs. Critically, interfering with RBM7 or P-TEFb provokes cellular hypersensitivity to DNA damage-inducing agents through activation of apoptotic program. By alleviating the inhibition of P-TEFb, RBM7 thus facilitates Pol II elongation to enable a pro-survival transcriptional response that is crucial for cell fate upon genotoxic insult. Our work uncovers a new paradigm in stress-dependent control of Pol II pause release, and offers the promise for designing novel anti-cancer interventions using RBM7 and P-TEFb antagonists in combination with DNA-damaging chemotherapeutics." @default.
- W2952248794 created "2019-06-27" @default.
- W2952248794 creator A5010083961 @default.
- W2952248794 creator A5024978770 @default.
- W2952248794 creator A5026093084 @default.
- W2952248794 creator A5031840988 @default.
- W2952248794 creator A5032596067 @default.
- W2952248794 creator A5040288107 @default.
- W2952248794 creator A5041087095 @default.
- W2952248794 creator A5042469564 @default.
- W2952248794 creator A5045717136 @default.
- W2952248794 creator A5047701680 @default.
- W2952248794 creator A5081029064 @default.
- W2952248794 creator A5081437536 @default.
- W2952248794 date "2018-08-17" @default.
- W2952248794 modified "2023-10-16" @default.
- W2952248794 title "P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress" @default.
- W2952248794 cites W1686821153 @default.
- W2952248794 cites W1834739414 @default.
- W2952248794 cites W1973091058 @default.
- W2952248794 cites W1973462980 @default.
- W2952248794 cites W1976021822 @default.
- W2952248794 cites W1976033223 @default.
- W2952248794 cites W1980861325 @default.
- W2952248794 cites W1981378173 @default.
- W2952248794 cites W1982602899 @default.
- W2952248794 cites W1984901090 @default.
- W2952248794 cites W1988313137 @default.
- W2952248794 cites W1990532502 @default.
- W2952248794 cites W1991221096 @default.
- W2952248794 cites W2011315564 @default.
- W2952248794 cites W2012451954 @default.
- W2952248794 cites W2020099265 @default.
- W2952248794 cites W2020911849 @default.
- W2952248794 cites W2026004604 @default.
- W2952248794 cites W2032828731 @default.
- W2952248794 cites W2036897871 @default.
- W2952248794 cites W2037429489 @default.
- W2952248794 cites W2038894647 @default.
- W2952248794 cites W2042039207 @default.
- W2952248794 cites W2046082575 @default.
- W2952248794 cites W2046085162 @default.
- W2952248794 cites W2049904360 @default.
- W2952248794 cites W2051598492 @default.
- W2952248794 cites W2052279652 @default.
- W2952248794 cites W2053293102 @default.
- W2952248794 cites W2057228860 @default.
- W2952248794 cites W2058953427 @default.
- W2952248794 cites W2061510891 @default.
- W2952248794 cites W2064128480 @default.
- W2952248794 cites W2067293798 @default.
- W2952248794 cites W2073364366 @default.
- W2952248794 cites W2076713615 @default.
- W2952248794 cites W2080155284 @default.
- W2952248794 cites W2080739841 @default.
- W2952248794 cites W2082161548 @default.
- W2952248794 cites W2087203611 @default.
- W2952248794 cites W2089529796 @default.
- W2952248794 cites W2092340900 @default.
- W2952248794 cites W2094646262 @default.
- W2952248794 cites W2096010243 @default.
- W2952248794 cites W2106391833 @default.
- W2952248794 cites W2106868003 @default.
- W2952248794 cites W2110010240 @default.
- W2952248794 cites W2114104545 @default.
- W2952248794 cites W2114532236 @default.
- W2952248794 cites W2120572492 @default.
- W2952248794 cites W2120780623 @default.
- W2952248794 cites W2125878780 @default.
- W2952248794 cites W2129188120 @default.
- W2952248794 cites W2130410032 @default.
- W2952248794 cites W2131009444 @default.
- W2952248794 cites W2133728532 @default.
- W2952248794 cites W2135229538 @default.
- W2952248794 cites W2136411119 @default.
- W2952248794 cites W2137840425 @default.
- W2952248794 cites W2138207763 @default.
- W2952248794 cites W2141337702 @default.
- W2952248794 cites W2145200068 @default.
- W2952248794 cites W2147863515 @default.
- W2952248794 cites W2148619403 @default.
- W2952248794 cites W2159011251 @default.
- W2952248794 cites W2159515687 @default.
- W2952248794 cites W2159812536 @default.
- W2952248794 cites W2162365619 @default.
- W2952248794 cites W2165710552 @default.
- W2952248794 cites W2226712470 @default.
- W2952248794 cites W2281629727 @default.
- W2952248794 cites W2283866230 @default.
- W2952248794 cites W2293620004 @default.
- W2952248794 cites W2330148258 @default.
- W2952248794 cites W2346138495 @default.
- W2952248794 cites W2357763069 @default.
- W2952248794 cites W2467821849 @default.
- W2952248794 cites W2558715875 @default.
- W2952248794 cites W2578822114 @default.
- W2952248794 cites W2588036404 @default.
- W2952248794 cites W2593095770 @default.
- W2952248794 cites W2602557812 @default.
- W2952248794 cites W2615878271 @default.