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- W2952256268 abstract "Quinolines substituted at C-2 on the quinoline scaffold have shown interesting anticancer activity in a number of anticancer assays such as breast (MCF-7, MDA-MB 231), human cervical epithelioid (HeLa), oral squamous cell carcinoma (SAS), human stomach adenocarcinoma (AGS, MKN45), hepatocellular (SKHep, HepG-2, Hep-3B), prostate (PC-3, DU145), lung (A549, H-460), gastric (HGC, MNK-74), leukemia (K562, U937, REH, NALM6, CEM/ADR 5000), colon (Colo-205, HCT 116, SW620, Caco-2, HT29), neuroblastoma (IMR32), CNS (SF-268), oesophageal (EAC) and melanoma (A-375). They have been synthesised by a number of strategies starting with isatin, anilines, nitrobenzenes and benzamides and some even with cyclohexanone and cyclohexa-1,3-diones with ammonium acetate. Many of the synthetic strategies employ the derivatisation of quinoline precursors itself. We review here the synthesis of 145 bioactive anticancer quinolines substituted at the 2-position and their anticancer activity." @default.
- W2952256268 created "2019-06-27" @default.
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- W2952256268 date "2015-09-01" @default.
- W2952256268 modified "2023-09-27" @default.
- W2952256268 title "ChemInform Abstract: A Review on the Synthesis and Anti-Cancer Activity of 2-Substituted Quinolines" @default.
- W2952256268 cites W2269397879 @default.
- W2952256268 doi "https://doi.org/10.1002/chin.201538256" @default.
- W2952256268 hasPublicationYear "2015" @default.
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