FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952261326> ?p ?o ?g. }

• W2952261326 abstract "Abstract Despite the development of several targeted therapies for rheumatoid arthritis (RA), there is still no reliable drug-specific predictor to assist rheumatologists in selecting the most effective targeted therapy for each patient. Recently, a gene signature caused by impaired induction of PTPN22 in anti-CD3 stimulated peripheral blood mononuclear cells (PBMC) was observed in healthy at-risk individuals. However, the downstream target genes of PTPN22 and the molecular mechanisms regulating its expression are still poorly understood. Here we report that the PTPN22 gene signature is also present in PBMC from patients with active RA and can be reversed after effective treatment. The expression of PTPN22 correlates with that of more than 1000 genes in Th cells of anti-CD3 stimulated PBMC of healthy donors and is inhibited by TNFα or CD28 signals, but not IL-6, through distinct mechanisms. In addition, the impaired induction of PTPN22 in PBMC of patients with active RA can be normalized in vitro by several targeted therapies. More importantly, the in vitro normalization of PTPN22 expression correlates with clinical response to the targeted therapies in a longitudinal RA cohort. Thus, in vitro normalization of PTPN22 expression by targeted therapies can potentially be used to predict clinical response in a drug-specific manner." @default.
• W2952261326 created "2019-06-27" @default.
• W2952261326 creator A5008664129 @default.
• W2952261326 creator A5024769661 @default.
• W2952261326 creator A5059078541 @default.
• W2952261326 creator A5060834917 @default.
• W2952261326 creator A5061556213 @default.
• W2952261326 creator A5062489482 @default.
• W2952261326 creator A5076698347 @default.
• W2952261326 creator A5082819294 @default.
• W2952261326 creator A5087363410 @default.
• W2952261326 date "2019-03-24" @default.
• W2952261326 modified "2023-10-02" @default.
• W2952261326 title "Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis" @default.
• W2952261326 cites W1968142189 @default.
• W2952261326 cites W1975639464 @default.
• W2952261326 cites W1979482663 @default.
• W2952261326 cites W1990678679 @default.
• W2952261326 cites W2019552331 @default.
• W2952261326 cites W2030232616 @default.
• W2952261326 cites W2043709854 @default.
• W2952261326 cites W2054355572 @default.
• W2952261326 cites W2056766867 @default.
• W2952261326 cites W2114768841 @default.
• W2952261326 cites W2120393706 @default.
• W2952261326 cites W2127818570 @default.
• W2952261326 cites W2130979463 @default.
• W2952261326 cites W2131168761 @default.
• W2952261326 cites W2139710449 @default.
• W2952261326 cites W2147302739 @default.
• W2952261326 cites W2151521102 @default.
• W2952261326 cites W2151954973 @default.
• W2952261326 cites W2309229101 @default.
• W2952261326 cites W2320348279 @default.
• W2952261326 cites W2341970630 @default.
• W2952261326 cites W2517073520 @default.
• W2952261326 cites W2554218802 @default.
• W2952261326 cites W2579080730 @default.
• W2952261326 cites W2765878422 @default.
• W2952261326 cites W2770914202 @default.
• W2952261326 doi "https://doi.org/10.1101/586982" @default.
• W2952261326 hasPublicationYear "2019" @default.
• W2952261326 type Work @default.
• W2952261326 sameAs 2952261326 @default.
• W2952261326 citedByCount "0" @default.
• W2952261326 crossrefType "posted-content" @default.
• W2952261326 hasAuthorship W2952261326A5008664129 @default.
• W2952261326 hasAuthorship W2952261326A5024769661 @default.
• W2952261326 hasAuthorship W2952261326A5059078541 @default.
• W2952261326 hasAuthorship W2952261326A5060834917 @default.
• W2952261326 hasAuthorship W2952261326A5061556213 @default.
• W2952261326 hasAuthorship W2952261326A5062489482 @default.
• W2952261326 hasAuthorship W2952261326A5076698347 @default.
• W2952261326 hasAuthorship W2952261326A5082819294 @default.
• W2952261326 hasAuthorship W2952261326A5087363410 @default.
• W2952261326 hasBestOaLocation W29522613261 @default.
• W2952261326 hasConcept C104317684 @default.
• W2952261326 hasConcept C135763542 @default.
• W2952261326 hasConcept C137061746 @default.
• W2952261326 hasConcept C150194340 @default.
• W2952261326 hasConcept C153209595 @default.
• W2952261326 hasConcept C202751555 @default.
• W2952261326 hasConcept C203014093 @default.
• W2952261326 hasConcept C2777575956 @default.
• W2952261326 hasConcept C2779356809 @default.
• W2952261326 hasConcept C2779733811 @default.
• W2952261326 hasConcept C54355233 @default.
• W2952261326 hasConcept C71924100 @default.
• W2952261326 hasConcept C86803240 @default.
• W2952261326 hasConceptScore W2952261326C104317684 @default.
• W2952261326 hasConceptScore W2952261326C135763542 @default.
• W2952261326 hasConceptScore W2952261326C137061746 @default.
• W2952261326 hasConceptScore W2952261326C150194340 @default.
• W2952261326 hasConceptScore W2952261326C153209595 @default.
• W2952261326 hasConceptScore W2952261326C202751555 @default.
• W2952261326 hasConceptScore W2952261326C203014093 @default.
• W2952261326 hasConceptScore W2952261326C2777575956 @default.
• W2952261326 hasConceptScore W2952261326C2779356809 @default.
• W2952261326 hasConceptScore W2952261326C2779733811 @default.
• W2952261326 hasConceptScore W2952261326C54355233 @default.
• W2952261326 hasConceptScore W2952261326C71924100 @default.
• W2952261326 hasConceptScore W2952261326C86803240 @default.
• W2952261326 hasLocation W29522613261 @default.
• W2952261326 hasOpenAccess W2952261326 @default.
• W2952261326 hasPrimaryLocation W29522613261 @default.
• W2952261326 hasRelatedWork W2017762858 @default.
• W2952261326 hasRelatedWork W2109869603 @default.
• W2952261326 hasRelatedWork W2124545683 @default.
• W2952261326 hasRelatedWork W2171698193 @default.
• W2952261326 hasRelatedWork W2412549144 @default.
• W2952261326 hasRelatedWork W2528985895 @default.
• W2952261326 hasRelatedWork W2530462654 @default.
• W2952261326 hasRelatedWork W2552598756 @default.
• W2952261326 hasRelatedWork W2752679580 @default.
• W2952261326 hasRelatedWork W2754012973 @default.
• W2952261326 hasRelatedWork W2922551927 @default.
• W2952261326 hasRelatedWork W2923864756 @default.
• W2952261326 hasRelatedWork W295409592 @default.
• W2952261326 hasRelatedWork W2956066087 @default.
• W2952261326 hasRelatedWork W2969852643 @default.

• next