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- W2952288242 abstract "By natural product inspired diversity-oriented synthesis, we had developed a new class of selective antagonist, IKM-159, for the AMPA receptor. Here, we report syntheses of IKM-159 and skeletally diverse five analogues in racemic forms, two of which are heterotricycles and the other three compounds are truncated analogues, to study the structure–activity relationships. The key reactions are two domino reactions including Ugi/Diels–Alder reaction and domino metathesis reaction. An exceptionally high level of regiocontrol in the cross metathesis reaction is also reported." @default.
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- W2952288242 date "2013-09-12" @default.
- W2952288242 modified "2023-10-09" @default.
- W2952288242 title "Biology- and Diversity-Oriented Domino Reactions for Synthesis of AMPA Receptor Antagonist IKM-159 and Analogues" @default.
- W2952288242 doi "https://doi.org/10.1055/s-0033-1338543" @default.
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