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- W2952293787 abstract "Serine and threonine analogues (compounds 2-6) are readily accessible by reaction of the anion of N,N-dibenzylglycine ethyl ester (1) with an appropriate carbonyl compound. These analogues will be incorporated into Protein Kinase C (PKC) substrates. The serine aldehyde derivative 7 was used for the preparation of the corresponding diethyl acetal 9. This compound was the starting material in the synthesis of the suicide precursor 8, featuring a reductive amination leading to 12 and a Lewis-acid-catalysed cyclization giving 8." @default.
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- W2952293787 date "2010-09-02" @default.
- W2952293787 modified "2023-09-25" @default.
- W2952293787 title "Synthesis of serine analogues to be used as modified phospho acceptor sites in substrates of protein kinase C" @default.
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- W2952293787 doi "https://doi.org/10.1002/recl.19911100204" @default.
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