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- W2952294086 abstract "Hairy cell leukemia (HCL) responds initially very well to chemotherapy with purine analogues. However, up to 50% of patients relapse, often multiple times, and become progressively less sensitive to these myelotoxic and immune-suppressive drugs. At progression, viable therapeutic strategies include addition of rituximab to purine analogues, and treatment with the anti-CD22 immunotoxin moxetumomab pasudotox, which has been recently approved by the FDA in HCL patients after at least two prior therapies. Identification of the BRAF-V600E kinase mutation as the genetic cause of HCL has opened the way, in the relapsed/refractory experimental setting, to targeted and non-myelotoxic effective strategies that are based on inhibition of BRAF with vemurafenib, co-inhibition of BRAF and its target MEK with dabrafenib and trametinib, and BRAF inhibition with vemurafenib combined with anti-CD20 immunotherapy. In particular, vemurafenib plus rituximab is emerging as a short, safe, chemotherapy-free regimen able to induce deep complete remissions in most HCL patients refractory to, or relapsed multiple times, after chemo(immuno)therapy." @default.
- W2952294086 created "2019-06-27" @default.
- W2952294086 creator A5008077055 @default.
- W2952294086 creator A5059848948 @default.
- W2952294086 date "2019-06-01" @default.
- W2952294086 modified "2023-09-26" @default.
- W2952294086 title "New treatment options in hairy cell leukemia with focus on BRAF inhibitors" @default.
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- W2952294086 doi "https://doi.org/10.1002/hon.2594" @default.
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